Literature DB >> 24981763

Molecular motors as drug delivery vehicles.

Richard N Cohen1, Mark J Rashkin2, Xin Wen2, Francis C Szoka3.   

Abstract

Molecular motors that make up the intracellular transport system are akin to subway cars and trains that ply the rails of cities. The inner workings of these extraordinarily complicated systems are being explicated at the atomic level at a phenomenal rate, and it is becoming apparent that we are on the verge of bioengineering these motors for specialized applications. These systems might be the key to yet unsolved biomedical applications that include non-viral gene therapy and interneuron drug delivery.:
© 2005 Elsevier Ltd . All rights reserved.

Year:  2005        PMID: 24981763     DOI: 10.1016/j.ddtec.2005.04.003

Source DB:  PubMed          Journal:  Drug Discov Today Technol        ISSN: 1740-6749


  5 in total

1.  Evaluation of an LC8-binding peptide for the attachment of artificial cargo to dynein.

Authors:  Jamie M Bergen; Suzie H Pun
Journal:  Mol Pharm       Date:  2007 Jan-Feb       Impact factor: 4.939

2.  Dynein light chain association sequences can facilitate nuclear protein import.

Authors:  Gregory W Moseley; Daniela Martino Roth; Michelle A DeJesus; Denisse L Leyton; Richard P Filmer; Colin W Pouton; David A Jans
Journal:  Mol Biol Cell       Date:  2007-06-13       Impact factor: 4.138

3.  Adenovirus in a synthetic membrane wrapper: an example of hybrid vigor?

Authors:  David H Thompson
Journal:  ACS Nano       Date:  2008-05       Impact factor: 15.881

4.  Peptide-modified vectors for nucleic acid delivery to neurons.

Authors:  E J Kwon; J M Bergen; I K Park; S H Pun
Journal:  J Control Release       Date:  2008-06-21       Impact factor: 9.776

5.  Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection.

Authors:  Richard N Cohen; Marieke A E M van der Aa; Nichole Macaraeg; Ai Ping Lee; Francis C Szoka
Journal:  J Control Release       Date:  2009-01-12       Impact factor: 9.776

  5 in total

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