Literature DB >> 18627784

Peptide-modified vectors for nucleic acid delivery to neurons.

E J Kwon1, J M Bergen, I K Park, S H Pun.   

Abstract

Neuron-targeted nucleic acid delivery systems are important technologies for realizing the potential of gene therapy for nervous system disorders. However, neurons are difficult cells to transfect using non-viral vectors due in part to the specific and unique delivery challenges present in these cells. We have investigated several bioactive peptides for their ability to assist in overcoming delivery barriers in mammalian cells. We summarize here our recent progress in developing and applying peptide-modified polycations for nucleic acid delivery. In addition, we present data demonstrating the potential of using multicomponent, peptide-modified polycations for nucleic acid delivery to neurons.

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Year:  2008        PMID： 18627784      PMCID： PMC2695844          DOI： 10.1016/j.jconrel.2008.06.012

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  47 in total

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2.  A novel peptide defined through phage display for therapeutic protein and vector neuronal targeting.

Authors:  James K Liu; Qingshan Teng; Mary Garrity-Moses; Thais Federici; Diana Tanase; Michael J Imperiale; Nicholas M Boulis
Journal:  Neurobiol Dis       Date:  2005-08       Impact factor: 5.996

3.  Evaluation of an LC8-binding peptide for the attachment of artificial cargo to dynein.

Authors:  Jamie M Bergen; Suzie H Pun
Journal:  Mol Pharm       Date:  2007 Jan-Feb       Impact factor: 4.939

4.  RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model.

Authors:  Scott Q Harper; Patrick D Staber; Xiaohua He; Steven L Eliason; Inês H Martins; Qinwen Mao; Linda Yang; Robert M Kotin; Henry L Paulson; Beverly L Davidson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-05       Impact factor: 11.205

5.  Gene delivery to the nervous system.

Authors:  Manfred Schubert; Xandra Breakefield; Howard Federoff; Robert M Frederickson; Pedro R Lowenstein
Journal:  Mol Ther       Date:  2008-04       Impact factor: 11.454

6.  Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER.

Authors:  L Pelkmans; J Kartenbeck; A Helenius
Journal:  Nat Cell Biol       Date:  2001-05       Impact factor: 28.824

7.  Retrograde transneuronal transfer of the C-fragment of tetanus toxin.

Authors:  P S Fishman; D R Carrigan
Journal:  Brain Res       Date:  1987-03-17       Impact factor: 3.252

8.  Application of an HIV gp41-derived peptide for enhanced intracellular trafficking of synthetic gene and siRNA delivery vehicles.

Authors:  Ester J Kwon; Jamie M Bergen; Suzie H Pun
Journal:  Bioconjug Chem       Date:  2008-04-01       Impact factor: 4.774

9.  Function of dynein and dynactin in herpes simplex virus capsid transport.

Authors:  Katinka Döhner; André Wolfstein; Ute Prank; Christophe Echeverri; Denis Dujardin; Richard Vallee; Beate Sodeik
Journal:  Mol Biol Cell       Date:  2002-08       Impact factor: 4.138

10.  Visualization of the intracellular behavior of HIV in living cells.

Authors:  David McDonald; Marie A Vodicka; Ginger Lucero; Tatyana M Svitkina; Gary G Borisy; Michael Emerman; Thomas J Hope
Journal:  J Cell Biol       Date:  2002-11-04       Impact factor: 10.539
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  12 in total

Review 1.  Exploiting endocytosis for nanomedicines.

Authors:  Akin Akinc; Giuseppe Battaglia
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-11-01       Impact factor: 10.005

2.  A truncated HGP peptide sequence that retains endosomolytic activity and improves gene delivery efficiencies.

Authors:  Ester J Kwon; Sylvie Liong; Suzie H Pun
Journal:  Mol Pharm       Date:  2010-08-02       Impact factor: 4.939

3.  HPMA-oligolysine copolymers for gene delivery: optimization of peptide length and polymer molecular weight.

Authors:  Russell N Johnson; David S H Chu; Julie Shi; Joan G Schellinger; Peter M Carlson; Suzie H Pun
Journal:  J Control Release       Date:  2011-07-14       Impact factor: 9.776

Review 4.  Gene-Modified Stem Cells for Spinal Cord Injury: a Promising Better Alternative Therapy.

Authors:  Yirui Feng; Yu Li; Ping-Ping Shen; Bin Wang
Journal:  Stem Cell Rev Rep       Date:  2022-05-19       Impact factor: 5.739

5.  Targeted nonviral delivery vehicles to neural progenitor cells in the mouse subventricular zone.

Authors:  Ester J Kwon; Jurate Lasiene; Berit E Jacobson; In-Kyu Park; Philip J Horner; Suzie H Pun
Journal:  Biomaterials       Date:  2009-12-09       Impact factor: 12.479

6.  Synthesis and characterization of biodegradable HPMA-oligolysine copolymers for improved gene delivery.

Authors:  Rob S Burke; Suzie H Pun
Journal:  Bioconjug Chem       Date:  2010-01       Impact factor: 4.774

7.  Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection.

Authors:  Richard N Cohen; Marieke A E M van der Aa; Nichole Macaraeg; Ai Ping Lee; Francis C Szoka
Journal:  J Control Release       Date:  2009-01-12       Impact factor: 9.776

8.  New polymer of lactic-co-glycolic acid-modified polyethylenimine for nucleic acid delivery.

Authors:  Jian-Ming Lü; Zhengdong Liang; Xiaoxiao Wang; Jianhua Gu; Qizhi Yao; Changyi Chen
Journal:  Nanomedicine (Lond)       Date:  2016-07-26       Impact factor: 5.307

Review 9.  Peptide-Modified Biopolymers for Biomedical Applications.

Authors:  Jessica Hersh; David Broyles; José Manuel Condor Capcha; Emre Dikici; Lina A Shehadeh; Sylvia Daunert; Sapna Deo
Journal:  ACS Appl Bio Mater       Date:  2020-12-24

Review 10.  Gene delivery strategies to promote spinal cord repair.

Authors:  Christopher M Walthers; Stephanie K Seidlits
Journal:  Biomark Insights       Date:  2015-04-09
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