Literature DB >> 24981624

Lipophilicity - beyond octanol/water: a short comparison of modern technologies.

Thorsten Hartmann1, Johannes Schmitt2.   

Abstract

Sorting out new chemical entities (NCE) with inappropriate absorption, distribution, metabolism, excretion (ADME) behaviour at an early stage of drug discovery and development is a major challenge in pharmaceutical profiling. An accepted strategy to predict absorption is the measurement of the permeability of a drug candidate. One step earlier the lipophilicity of a compound is determined, which is directly related to permeability and fraction absorbed. Here, we compare today's state of the art technologies for a fast measurement of lipophilicity.:
© 2004 Elsevier Ltd . All rights reserved.

Entities:  

Year:  2004        PMID： 24981624     DOI： 10.1016/j.ddtec.2004.10.006

Source DB:  PubMed          Journal:  Drug Discov Today Technol        ISSN： 1740-6749


  9 in total

1.  Theoretical and experimental study on lipophilicity and wound healing activity of ginger compounds.

Authors:  Mohammed Afroz Bakht; Mohammed F Alajmi; Perwez Alam; Aftab Alam; Prawez Alam; Tariq Mohammed Aljarba
Journal:  Asian Pac J Trop Biomed       Date:  2014-04

2.  Estimating the Lipophilicity of Natural Products using a Polymeric Reversed Phase HPLC Method.

Authors:  Bo Zheng; Lyndon M West
Journal:  J Liq Chromatogr Relat Technol       Date:  2009-12-11       Impact factor: 1.312

3.  Investigation of Hydro-Lipophilic Properties of N-Alkoxyphenylhydroxynaphthalenecarboxamides †.

Authors:  Iva Kapustikova; Andrzej Bak; Tomas Gonec; Jiri Kos; Violetta Kozik; Josef Jampilek
Journal:  Molecules       Date:  2018-07-04       Impact factor: 4.411

4.  A Fully Integrated Assay Panel for Early Drug Metabolism and Pharmacokinetics Profiling.

Authors:  Johan Wernevik; Fredrik Bergström; Anna Novén; Johan Hulthe; Linda Fredlund; Dan Addison; Jan Holmgren; Per-Erik Strömstedt; Erika Rehnström; Thomas Lundböck
Journal:  Assay Drug Dev Technol       Date:  2020-05-14       Impact factor: 1.738

5.  Investigating biological activity spectrum for novel styrylquinazoline analogues.

Authors:  Josef Jampilek; Robert Musiol; Jacek Finster; Matus Pesko; James Carroll; Katarina Kralova; Marcela Vejsova; Jim O'Mahony; Aidan Coffey; Jiri Dohnal; Jaroslaw Polanski
Journal:  Molecules       Date:  2009-10-23       Impact factor: 4.411

6.  Rhodanineacetic acid derivatives as potential drugs: preparation, hydrophobic properties and antifungal activity of (5-arylalkylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)acetic acids.

Authors:  Jan Dolezel; Petra Hirsova; Veronika Opletalova; Jiri Dohnal; Vejsova Marcela; Jiri Kunes; Josef Jampilek
Journal:  Molecules       Date:  2009-10-20       Impact factor: 4.411

7.  The Application of CA and PCA to the Evaluation of Lipophilicity and Physicochemical Properties of Tetracyclic Diazaphenothiazine Derivatives.

Authors:  Anna Nycz-Empel; Katarzyna Bober; Mirosław Wyszomirski; Ewa Kisiel; Andrzej Zięba
Journal:  J Anal Methods Chem       Date:  2019-10-20       Impact factor: 2.193

8.  Assessment of Lipophilicity Descriptors of Selected NSAIDs Obtained at Different TLC Stationary Phases.

Authors:  Małgorzata Starek; Alina Plenis; Marta Zagrobelna; Monika Dąbrowska
Journal:  Pharmaceutics       Date:  2021-03-24       Impact factor: 6.321

9.  Structural Basis of 2-Phenylamino-4-phenoxyquinoline Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.

Authors:  Arthit Makarasen; Suwicha Patnin; Pongsit Vijitphan; Nanthawan Reukngam; Panita Khlaychan; Mayuso Kuno; Pakamas Intachote; Busakorn Saimanee; Suchada Sengsai; Supanna Techasakul
Journal:  Molecules       Date:  2022-01-11       Impact factor: 4.411
  9 in total

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