Literature DB >> 26396911

Development of anticancer agents targeting the Wnt/β-catenin signaling.

Xiangqian Zhang1, Jijun Hao2.   

Abstract

Wnt/β-catenin signaling plays indispensable roles in both embryonic development and adult homeostasis. Abnormal regulation of this pathway is implicated in many types of cancer. Consequently, substantial efforts have made to develop therapeutic agents as anticancer drugs by specifically targeting the Wnt/β-catenin pathway. Here we systematically review the potential therapeutic agents that have been developed to date for inhibition of the Wnt/β-catenin cascade as well as current status of clinical trials of some of these agents.

Entities:  

Keywords:  Wnt/β-catenin signaling; biologic agents; cancer; safety and clinic; small molecules; therapeutic; β-catenin

Year:  2015        PMID： 26396911      PMCID： PMC4568771     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  115 in total

1.  Symmetric division versus asymmetric division: a tale of two coactivators.

Authors:  Michael Kahn
Journal:  Future Med Chem       Date:  2011-10       Impact factor: 3.808

2.  Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.

Authors:  Curtis A Thorne; Alison J Hanson; Judsen Schneider; Emilios Tahinci; Darren Orton; Christopher S Cselenyi; Kristin K Jernigan; Kelly C Meyers; Brian I Hang; Alex G Waterson; Kwangho Kim; Bruce Melancon; Victor P Ghidu; Gary A Sulikowski; Bonnie LaFleur; Adrian Salic; Laura A Lee; David M Miller; Ethan Lee
Journal:  Nat Chem Biol       Date:  2010-10-03       Impact factor: 15.040

Review 3.  The intestinal stem cell.

Authors:  Nick Barker; Marc van de Wetering; Hans Clevers
Journal:  Genes Dev       Date:  2008-07-15       Impact factor: 11.361

4.  Pyrvinium pamoate does not activate protein kinase CK1, but promotes Akt/PKB down-regulation and GSK3 activation.

Authors:  Andrea Venerando; Cristina Girardi; Maria Ruzzene; Lorenzo A Pinna
Journal:  Biochem J       Date:  2013-05-15       Impact factor: 3.857

5.  Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis.

Authors:  Marco Chilosi; Venerino Poletti; Alberto Zamò; Maurizio Lestani; Licia Montagna; Paola Piccoli; Serena Pedron; Manuela Bertaso; Aldo Scarpa; Bruno Murer; Alessandra Cancellieri; Roberta Maestro; Gianpietro Semenzato; Claudio Doglioni
Journal:  Am J Pathol       Date:  2003-05       Impact factor: 4.307

6.  Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation.

Authors:  Long Zhang; Xia Gao; Jun Wen; Yuanheng Ning; Ye-Guang Chen
Journal:  J Biol Chem       Date:  2006-01-30       Impact factor: 5.157

7.  Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.

Authors:  R Nusse; H E Varmus
Journal:  Cell       Date:  1982-11       Impact factor: 41.582

8.  A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected].

Authors:  Katayoon H Emami; Cu Nguyen; Hong Ma; Dae Hoon Kim; Kwang Won Jeong; Masakatsu Eguchi; Randall T Moon; Jia-Ling Teo; Se Woong Oh; Hak Yeop Kim; Sung Hwan Moon; Jong Ryul Ha; Michael Kahn
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-16       Impact factor: 11.205

9.  Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled.

Authors:  D J Sussman; J Klingensmith; P Salinas; P S Adams; R Nusse; N Perrimon
Journal:  Dev Biol       Date:  1994-11       Impact factor: 3.582

10.  Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis.

Authors:  X Li; V Placencio; J M Iturregui; C Uwamariya; A-R Sharif-Afshar; T Koyama; S W Hayward; N A Bhowmick
Journal:  Oncogene       Date:  2008-08-25       Impact factor: 9.867
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  45 in total

1.  Wnt/β-catenin Signaling Contributes to Tumor Malignancy and Is Targetable in Gastrointestinal Stromal Tumor.

Authors:  Shan Zeng; Adrian M Seifert; Jennifer Q Zhang; Michael J Cavnar; Teresa S Kim; Vinod P Balachandran; Juan A Santamaria-Barria; Noah A Cohen; Michael J Beckman; Benjamin D Medina; Ferdinand Rossi; Megan H Crawley; Jennifer K Loo; Joanna H Maltbaek; Peter Besmer; Cristina R Antonescu; Ronald P DeMatteo
Journal:  Mol Cancer Ther       Date:  2017-06-13       Impact factor: 6.261

Review 2.  Revisiting the role of Wnt/β-catenin signaling in prostate cancer.

Authors:  Jeffrey A Schneider; Susan K Logan
Journal:  Mol Cell Endocrinol       Date:  2017-02-09       Impact factor: 4.102

Review 3.  Systemic Management for Advanced Hepatocellular Carcinoma: A Review of the Molecular Pathways of Carcinogenesis, Current and Emerging Therapies, and Novel Treatment Strategies.

Authors:  Saad Saffo; Tamar H Taddei
Journal:  Dig Dis Sci       Date:  2019-04       Impact factor: 3.199

4.  Expression of β-catenin protein in hepatocellular carcinoma and its relationship with alpha-fetoprotein.

Authors:  Ya-Jun Ren; Tao Huang; Hong-Lu Yu; Li Zhang; Qian-Jin He; Zhi-Fan Xiong; Hua Peng
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2016-12-07

Review 5.  Recent Development of Wnt Signaling Pathway Inhibitors for Cancer Therapeutics.

Authors:  Jerry Harb; Pen-Jen Lin; Jijun Hao
Journal:  Curr Oncol Rep       Date:  2019-02-04       Impact factor: 5.075

6.  Surprising Enhancement of Fibrosis by Tubule-Specific Deletion of the TGF-β Receptor: A New Twist on an Old Paradigm.

Authors:  David P Basile; Purvi Mehrotra
Journal:  J Am Soc Nephrol       Date:  2017-10-26       Impact factor: 10.121

Review 7.  The potential role of CacyBP/SIP in tumorigenesis.

Authors:  Xiaoxuan Ning; Yang Chen; Xiaosu Wang; Qiaoneng Li; Shiren Sun
Journal:  Tumour Biol       Date:  2016-02-13

Review 8.  Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies.

Authors:  Kristin G Anderson; Ingunn M Stromnes; Philip D Greenberg
Journal:  Cancer Cell       Date:  2017-03-13       Impact factor: 31.743

9.  Genetic Heterogeneity in Therapy-Naïve Synchronous Primary Breast Cancers and Their Metastases.

Authors:  Charlotte K Y Ng; Francois-Clement Bidard; Salvatore Piscuoglio; Felipe C Geyer; Raymond S Lim; Ino de Bruijn; Ronglai Shen; Fresia Pareja; Samuel H Berman; Lu Wang; Jean-Yves Pierga; Anne Vincent-Salomon; Agnes Viale; Larry Norton; Brigitte Sigal; Britta Weigelt; Paul Cottu; Jorge S Reis-Filho
Journal:  Clin Cancer Res       Date:  2017-03-28       Impact factor: 12.531

10.  Pteisolic acid G, a novel ent-kaurane diterpenoid, inhibits viability and induces apoptosis in human colorectal carcinoma cells.

Authors:  Shuangli Qiu; Xin Wu; Hongbo Liao; Xiaobin Zeng; Senwang Zhang; Xiaofen Lu; Xiaohong He; Xiaoqi Zhang; Wencai Ye; Hua Wu; Xiaohui Zhu
Journal:  Oncol Lett       Date:  2017-09-06       Impact factor: 2.967
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