Kumaran Deiva1, Maria Carmela Pera2, Hélène Maurey2, Pascale Chrétien3, Frédérique Archambaud4, Viviane Bouilleret5, Marc Tardieu6. 1. Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital Bicêtre, Pediatric Neurology Department, Le Kremlin Bicêtre, France; National Referral Center for Neuro-Inflammatory Diseases in Children and University Paris-Sud, Le Kremlin-Bicêtre, France. Electronic address: kumaran.deiva@bct.aphp.fr. 2. Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital Bicêtre, Pediatric Neurology Department, Le Kremlin Bicêtre, France. 3. Assistance Publique Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital Bicêtre, Immunology Department, Le Kremlin-Bicêtre, France. 4. Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Biophysics and Nuclear Medecine Department, Le Kremlin-Bicêtre, France. 5. Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Neurophysiology and Epileptology Departement, Le Kremlin-Bicêtre, France. 6. Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital Bicêtre, Pediatric Neurology Department, Le Kremlin Bicêtre, France; National Referral Center for Neuro-Inflammatory Diseases in Children and University Paris-Sud, Le Kremlin-Bicêtre, France.
Abstract
BACKGROUND: Anti NMDA receptor (anti NMDAR) encephalitis is a well-characterized entity in children associating movement disorders, psychiatric features and speech difficulties. Novel phenotypes have been described in adults. METHODS AND RESULTS: A 4-year-old girl presented partial seizures which evolved towards sudden and isolated Broca's aphasia. Anti NMDAR antibodies were positive in CSF and serum confirming anti NMDAR encephalitis. Clinical recovery was observed after a specific treatment. CONCLUSION: This case widens the clinical spectrum of anti-NMDAR encephalitis in children and awareness of this newly identified symptom is important as early treatment is a predictor of good outcome.
BACKGROUND: Anti NMDA receptor (anti NMDAR) encephalitis is a well-characterized entity in children associating movement disorders, psychiatric features and speech difficulties. Novel phenotypes have been described in adults. METHODS AND RESULTS: A 4-year-old girl presented partial seizures which evolved towards sudden and isolated Broca's aphasia. Anti NMDAR antibodies were positive in CSF and serum confirming anti NMDAR encephalitis. Clinical recovery was observed after a specific treatment. CONCLUSION: This case widens the clinical spectrum of anti-NMDAR encephalitis in children and awareness of this newly identified symptom is important as early treatment is a predictor of good outcome.
Authors: David Mechelhoff; Betteke Maria van Noort; Bernhard Weschke; Christian J Bachmann; Christiane Wagner; Ernst Pfeiffer; Sibylle Winter Journal: Eur Child Adolesc Psychiatry Date: 2015-02-08 Impact factor: 4.785