OBJECTIVE: The aim of this study was to objectify changes in volume and density of treated and untreated pulmonary lobes following endobronchial coiling for lung volume reduction by comparison with clinical (6-m walk test) and pulmonary function tests. METHODS: Twenty-two lobes in 17 patients (8 men, 9 women) were treated by endobronchial coiling and underwent preinterventional and postinterventional computed tomography examinations (inspiratory and expiratory phase) as well as pulmonary function test measurements. RESULTS: Responders (n = 14) presented a significant increase (70 ± 11 m) in the walking distance (6-m walk test) and FEV1 (forced expiratory volume in 1 second) values (61 ± 21 mL). Only in responders inspiratory volume (VolIn) of the target lobe significantly decreased (10.0% ± 16.4%; P = 0.0245), and VolIn of the nontreated ipsilateral lobe significantly increased (5.5% ± 9.1%; P = 0.0209). CONCLUSIONS: Our results objectify volume reduction of the treated lobe coupled by a significant volume expansion of the ipsilateral lobe as a sole correlate for clinical improvement in responders.
OBJECTIVE: The aim of this study was to objectify changes in volume and density of treated and untreated pulmonary lobes following endobronchial coiling for lung volume reduction by comparison with clinical (6-m walk test) and pulmonary function tests. METHODS: Twenty-two lobes in 17 patients (8 men, 9 women) were treated by endobronchial coiling and underwent preinterventional and postinterventional computed tomography examinations (inspiratory and expiratory phase) as well as pulmonary function test measurements. RESULTS: Responders (n = 14) presented a significant increase (70 ± 11 m) in the walking distance (6-m walk test) and FEV1 (forced expiratory volume in 1 second) values (61 ± 21 mL). Only in responders inspiratory volume (VolIn) of the target lobe significantly decreased (10.0% ± 16.4%; P = 0.0245), and VolIn of the nontreated ipsilateral lobe significantly increased (5.5% ± 9.1%; P = 0.0209). CONCLUSIONS: Our results objectify volume reduction of the treated lobe coupled by a significant volume expansion of the ipsilateral lobe as a sole correlate for clinical improvement in responders.
Authors: Christopher Kloth; Wolfgang Maximilian Thaiss; Hendrik Ditt; Jürgen Hetzel; Eva Schülen; Konstantin Nikolaou; Marius Horger Journal: J Thorac Dis Date: 2016-12 Impact factor: 2.895
Authors: Christopher Kloth; Wolfgang Maximilian Thaiss; Jan Fritz; Konstantin Nikolaou; Meinrad Beer; Jürgen Hetzel; Sorin Dumitru Ioanoviciu; Marius Horger Journal: J Thorac Dis Date: 2019-01 Impact factor: 2.895