Swen Hesse1, Elsmarieke van de Giessen2, Franziska Zientek3, David Petroff4, Karsten Winter5, John C Dickson6, Livia Tossici-Bolt7, Terez Sera8, Susanne Asenbaum9, Jacques Darcourt10, Umit O Akdemir11, Gitte M Knudsen12, Flavio Nobili13, Marco Pagani14, Thierry Vander Borght15, Koen Van Laere16, Andrea Varrone17, Klaus Tatsch18, Osama Sabri19, Jan Booij2. 1. Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany; Leipzig University Medical Center, Integrated Research and Treatment Centre (IFB) Adiposity Diseases, Leipzig, Germany. Electronic address: swen.hesse@medizin.uni-leipzig.de. 2. Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 3. Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany. 4. Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany; Centre for Clinical Studies, Leipzig, Germany. 5. Translational Centre for Regenerative Medicine (TRM) Leipzig, Germany. 6. Institute of Nuclear Medicine, University College London Hospital, London, UK. 7. Department of Medical Physics and Bioengineering, Southampton University Hospitals NHS Trust, Southampton, UK. 8. University of Szeged, Department of Nuclear Medicine and Euromedic Szeged, Szeged, Hungary. 9. Department of Nuclear Medicine, Medical University of Vienna, Austria. 10. Nuclear Medicine Department, Centre Antoine Lacassagne, University of Nice-Sophia Antipolis, Nice, France. 11. Department of Nuclear Medicine, Gazi University, Faculty of Medicine, Ankara, Turkey. 12. Neurobiology Research Unit, Rigshospitalet - University of Copenhagen, Copenhagen, Denmark. 13. Clinical Neurophysiology Unit, Department of Neuroscience, Ophthalmology and Genetics, San Martino Hospital, University of Genoa, Genoa, Italy. 14. Department of Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden; Institute of Cognitive Sciences and Technologies, CNR, Rome & Padua, Italy. 15. Nuclear Medicine Division, Université Catholique de Louvain, Mont-Godinne Medical Center, Louvain-la-Neuve, Belgium. 16. Nuclear Medicine, University Hospital, K.U. Leuven, Leuven, Belgium. 17. Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden. 18. Department of Nuclear Medicine, University of Munich, Munich, Germany; Department of Nuclear Medicine, Municipal Hospital Karlsruhe Inc., Karlsruhe, Germany. 19. Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany; Leipzig University Medical Center, Integrated Research and Treatment Centre (IFB) Adiposity Diseases, Leipzig, Germany.
Abstract
UNLABELLED: Serotonin-mediated mechanisms, in particular via the serotonin transporter (SERT), are thought to have an effect on food intake and play an important role in the pathophysiology of obesity. However, imaging studies that examined the correlation between body mass index (BMI) and SERT are sparse and provided contradictory results. The aim of this study was to further test the association between SERT and BMI in a large cohort of healthy subjects. METHODS: 127 subjects of the ENC DAT database (58 females, age 52 ± 18 years, range 20-83, BMI 25.2 ± 3.8 kg/m(2), range 18.2-41.1) were analysed using region-of-interest (ROI) and voxel-based approaches to calculate [(123)I]FP-CIT specific-to-nonspecific binding ratios (SBR) in the hypothalamus/thalamus and midbrain/brainstem as SERT-specific target regions. RESULTS: In the voxel-based analysis, SERT availability and BMI were positively associated in the thalamus, but not in the midbrain. In the ROI-analysis, the interaction between gender and BMI showed a trend with higher correlation coefficient for men in the midbrain albeit not significant (0.033SBRm(2)/kg, p=0.1). CONCLUSIONS: The data are in agreement with previous PET findings of an altered central serotonergic tone depending on BMI, as a probable pathophysiologic mechanism in obesity, and should encourage further clinical studies in obesity targeting the serotonergic system.
UNLABELLED: Serotonin-mediated mechanisms, in particular via the serotonin transporter (SERT), are thought to have an effect on food intake and play an important role in the pathophysiology of obesity. However, imaging studies that examined the correlation between body mass index (BMI) and SERT are sparse and provided contradictory results. The aim of this study was to further test the association between SERT and BMI in a large cohort of healthy subjects. METHODS: 127 subjects of the ENC DAT database (58 females, age 52 ± 18 years, range 20-83, BMI 25.2 ± 3.8 kg/m(2), range 18.2-41.1) were analysed using region-of-interest (ROI) and voxel-based approaches to calculate [(123)I]FP-CIT specific-to-nonspecific binding ratios (SBR) in the hypothalamus/thalamus and midbrain/brainstem as SERT-specific target regions. RESULTS: In the voxel-based analysis, SERT availability and BMI were positively associated in the thalamus, but not in the midbrain. In the ROI-analysis, the interaction between gender and BMI showed a trend with higher correlation coefficient for men in the midbrain albeit not significant (0.033SBRm(2)/kg, p=0.1). CONCLUSIONS: The data are in agreement with previous PET findings of an altered central serotonergic tone depending on BMI, as a probable pathophysiologic mechanism in obesity, and should encourage further clinical studies in obesity targeting the serotonergic system.
Authors: J Melasch; M Rullmann; A Hilbert; J Luthardt; G A Becker; M Patt; M Stumvoll; M Blüher; A Villringer; K Arelin; P M Meyer; A Bresch; O Sabri; S Hesse; B Pleger Journal: Int J Obes (Lond) Date: 2016-04-22 Impact factor: 5.095
Authors: Swen Hesse; Michael Rullmann; Julia Luthardt; Karsten Winter; Mohammed K Hankir; Georg-Alexander Becker; Franziska Zientek; Georg Reissig; Ralf Regenthal; Mandy Drabe; Christian Schinke; Anke Bresch; Katrin Arelin; Donald Lobsien; Marianne Patt; Philipp M Meyer; Mathias Fasshauer; Wiebke K Fenske; Matthias Blüher; Michael Stumvoll; Osama Sabri Journal: Eur J Nucl Med Mol Imaging Date: 2015-11-18 Impact factor: 9.236
Authors: Molly J Crockett; Jenifer Z Siegel; Zeb Kurth-Nelson; Olga T Ousdal; Giles Story; Carolyn Frieband; Johanna M Grosse-Rueskamp; Peter Dayan; Raymond J Dolan Journal: Curr Biol Date: 2015-07-02 Impact factor: 10.834