Swen Hesse1,2, Michael Rullmann3,4,5, Julia Luthardt3, Karsten Winter6,7, Mohammed K Hankir4, Georg-Alexander Becker3, Franziska Zientek4, Georg Reissig4, Ralf Regenthal8, Mandy Drabe4, Christian Schinke9, Anke Bresch3, Katrin Arelin5,10, Donald Lobsien11, Marianne Patt3, Philipp M Meyer3, Mathias Fasshauer4,12, Wiebke K Fenske4,12, Matthias Blüher12,13, Michael Stumvoll4,12, Osama Sabri3,4. 1. Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany. swen.hesse@medizin.uni-leipzig.de. 2. Integrated Research and Treatment Centre Adiposity Diseases Leipzig, Leipzig, Germany. swen.hesse@medizin.uni-leipzig.de. 3. Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany. 4. Integrated Research and Treatment Centre Adiposity Diseases Leipzig, Leipzig, Germany. 5. Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Leipzig, Germany. 6. Centre for Translational Regenerative Medicine, University of Leipzig, Leipzig, Germany. 7. Institute for Medical Informatics, Statistics, and Epidemiology, University of Leipzig, Leipzig, Germany. 8. Division of Clinical Pharmacology, Rudolf Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany. 9. Department of Neurology, University of Leipzig, Leipzig, Germany. 10. Day Clinic for Cognitive Neurology, University of Leipzig, Leipzig, Germany. 11. Department of Neuroradiology, University of Leipzig, Leipzig, Germany. 12. Medical Department III, University of Leipzig, Leipzig, Germany. 13. Collaborative Research Centre 1052 Obesity Mechanisms, University of Leipzig, Leipzig, Germany.
Abstract
PURPOSE: The role of the central serotonin (5-hydroxytryptamine, 5-HT) system in feeding has been extensively studied in animals with the 5-HT family of transporters (5-HTT) being identified as key molecules in the regulation of satiety and body weight. Aberrant 5-HT transmission has been implicated in the pathogenesis of human obesity by in vivo positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging techniques. However, results obtained thus far from studies of central 5-HTT availability have been inconsistent, which is thought to be brought about mainly by the low number of individuals with a high body mass index (BMI) previously used. The aim of this study was therefore to assess 5-HTT availability in the brains of highly obese otherwise healthy individuals compared with non-obese healthy controls. METHODS: We performed PET using the 5-HTT selective radiotracer [(11)C] DASB on 30 highly obese (BMI range between 35 and 55 kg/m(2)) and 15 age- and sex-matched non-obese volunteers (BMI range between 19 and 27 kg/m(2)) in a cross-sectional study design. The 5-HTT binding potential (BPND) was used as the outcome parameter. RESULTS: On a group level, there was no significant difference in 5-HTT BPND in various cortical and subcortical regions in individuals with the highest BMI compared with non-obese controls, while statistical models showed minor effects of age, sex, and the degree of depression on 5-HTT BPND. CONCLUSION: The overall finding of a lack of significantly altered 5-HTT availability together with its high variance in obese individuals justifies the investigation of individual behavioral responses to external and internal cues which may further define distinct phenotypes and subgroups in human obesity.
PURPOSE: The role of the central serotonin (5-hydroxytryptamine, 5-HT) system in feeding has been extensively studied in animals with the 5-HT family of transporters (5-HTT) being identified as key molecules in the regulation of satiety and body weight. Aberrant 5-HT transmission has been implicated in the pathogenesis of humanobesity by in vivo positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging techniques. However, results obtained thus far from studies of central 5-HTT availability have been inconsistent, which is thought to be brought about mainly by the low number of individuals with a high body mass index (BMI) previously used. The aim of this study was therefore to assess 5-HTT availability in the brains of highly obese otherwise healthy individuals compared with non-obese healthy controls. METHODS: We performed PET using the 5-HTT selective radiotracer [(11)C] DASB on 30 highly obese (BMI range between 35 and 55 kg/m(2)) and 15 age- and sex-matched non-obese volunteers (BMI range between 19 and 27 kg/m(2)) in a cross-sectional study design. The 5-HTT binding potential (BPND) was used as the outcome parameter. RESULTS: On a group level, there was no significant difference in 5-HTT BPND in various cortical and subcortical regions in individuals with the highest BMI compared with non-obese controls, while statistical models showed minor effects of age, sex, and the degree of depression on 5-HTT BPND. CONCLUSION: The overall finding of a lack of significantly altered 5-HTT availability together with its high variance in obese individuals justifies the investigation of individual behavioral responses to external and internal cues which may further define distinct phenotypes and subgroups in humanobesity.
Entities:
Keywords:
Body mass index (BMI); Depression; Obesity; Positron emission tomography (PET); Serotonin; Serotonin transporter
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