PURPOSE: The aim of this study was to determine the utility of the peritoneal lavage cytology findings in predicting the clinical outcomes of resectable left-sided pancreatic cancer. METHODS: Peritoneal lavage samples were collected from 39 consecutive patients who underwent surgery for left-sided pancreatic cancer between January 2000 and December 2010. We analyzed the correlations between the peritoneal lavage cytology findings and the clinical outcomes. RESULTS: Five patients (12.8 %) had malignant cells in the cytology samples (positive cytology). This occurred more frequently in patients with vascular invasion (P = 0.008). Positive cytology was significantly associated with lower overall (P = 0.0007) and recurrent-free (P < 0.0001) survival rates. Positive cytology was an independent prognostic factor for recurrence (P = 0.022); it was closely associated with local recurrence, peritoneal recurrence and distant metastasis. CONCLUSION: Surgeons should carefully consider the intraoperative diagnosis of peritoneal lavage cytology in patients with resectable left-sided pancreatic cancers, because patients with positive cytology are likely to experience recurrence.
PURPOSE: The aim of this study was to determine the utility of the peritoneal lavage cytology findings in predicting the clinical outcomes of resectable left-sided pancreatic cancer. METHODS: Peritoneal lavage samples were collected from 39 consecutive patients who underwent surgery for left-sided pancreatic cancer between January 2000 and December 2010. We analyzed the correlations between the peritoneal lavage cytology findings and the clinical outcomes. RESULTS: Five patients (12.8 %) had malignant cells in the cytology samples (positive cytology). This occurred more frequently in patients with vascular invasion (P = 0.008). Positive cytology was significantly associated with lower overall (P = 0.0007) and recurrent-free (P < 0.0001) survival rates. Positive cytology was an independent prognostic factor for recurrence (P = 0.022); it was closely associated with local recurrence, peritoneal recurrence and distant metastasis. CONCLUSION: Surgeons should carefully consider the intraoperative diagnosis of peritoneal lavage cytology in patients with resectable left-sided pancreatic cancers, because patients with positive cytology are likely to experience recurrence.
Authors: Cristina R Ferrone; Barbara Haas; Laura Tang; Daniel G Coit; Yuman Fong; Murray F Brennan; Peter J Allen Journal: J Gastrointest Surg Date: 2006-12 Impact factor: 3.452
Authors: Helmut Oettle; Stefan Post; Peter Neuhaus; Klaus Gellert; Jan Langrehr; Karsten Ridwelski; Harald Schramm; Joerg Fahlke; Carl Zuelke; Christof Burkart; Klaus Gutberlet; Erika Kettner; Harald Schmalenberg; Karin Weigang-Koehler; Wolf-Otto Bechstein; Marco Niedergethmann; Ingo Schmidt-Wolf; Lars Roll; Bernd Doerken; Hanno Riess Journal: JAMA Date: 2007-01-17 Impact factor: 56.272
Authors: K D Lillemoe; J L Cameron; C J Yeo; T A Sohn; A Nakeeb; P K Sauter; R H Hruban; R A Abrams; H A Pitt Journal: Gastroenterology Date: 1997-03 Impact factor: 22.682