Literature DB >> 2497438

Activation of atrial muscarinic K+ channels by low concentrations of beta gamma subunits of rat brain G protein.

Y Kurachi1, H Ito, T Sugimoto, T Katada, M Ui.   

Abstract

Effects of G protein beta gamma subunits from rat brain on cardiac K+ channel was examined in single atrial cells of guinea-pig, using patch clamp techniques. We found that 10 pM concentration of rat brain beta gamma subunits preparation could activate the atrial muscarine receptor-gated K+ channel (IK.ACh). Neither the detergent, CHAPS, used to suspend beta gamma nor the boiled beta gamma preparation activated IK.ACh. Furthermore, preincubation of beta gamma subunits preparation in Mg2+-free solution, which easily inactivated alpha-GTP-gamma S, did not affect beta gamma-activation of IK.ACh. We concluded, therefore, that beta gamma subunits themselves can activate IK.ACh.

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Year:  1989        PMID： 2497438     DOI： 10.1007/bf00583550

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  15 in total

1.  The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.

Authors:  D E Logothetis; Y Kurachi; J Galper; E J Neer; D E Clapham
Journal:  Nature       Date:  1987 Jan 22-28       Impact factor: 49.962

2.  Direct activation of mammalian atrial muscarinic potassium channels by GTP regulatory protein Gk.

Authors:  A Yatani; J Codina; A M Brown; L Birnbaumer
Journal:  Science       Date:  1987-01-09       Impact factor: 47.728

3.  G protein opening of K+ channels.

Authors:  L Birnbaumer; A M Brown
Journal:  Nature       Date:  1987 May 7-13       Impact factor: 49.962

4.  Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.

Authors:  C L Jelsema; J Axelrod
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

5.  A new GTP-binding protein in brain tissues serving as the specific substrate of islet-activating protein, pertussis toxin.

Authors:  T Katada; M Oinuma; K Kusakabe; M Ui
Journal:  FEBS Lett       Date:  1987-03-23       Impact factor: 4.124

6.  On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins.

Authors:  Y Kurachi; T Nakajima; T Sugimoto
Journal:  Pflugers Arch       Date:  1986-09       Impact factor: 3.657

7.  Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities.

Authors:  T Katada; M Oinuma; M Ui
Journal:  J Biol Chem       Date:  1986-06-25       Impact factor: 5.157

8.  Uncoupling of cardiac muscarinic and beta-adrenergic receptors from ion channels by a guanine nucleotide analogue.

Authors:  G E Breitwieser; G Szabo
Journal:  Nature       Date:  1985 Oct 10-16       Impact factor: 49.962

9.  Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel.

Authors:  D E Logothetis; D H Kim; J K Northup; E J Neer; D E Clapham
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

10.  The alpha subunit of the GTP binding protein Gk opens atrial potassium channels.

Authors:  J Codina; A Yatani; D Grenet; A M Brown; L Birnbaumer
Journal:  Science       Date:  1987-04-24       Impact factor: 47.728
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  12 in total

Review 1.  The expanding roles and mechanisms of G protein-mediated presynaptic inhibition.

Authors:  Zack Zurawski; Yun Young Yim; Simon Alford; Heidi E Hamm
Journal:  J Biol Chem       Date:  2019-02-01       Impact factor: 5.157

2.  Positive cooperativity in activation of the cardiac muscarinic K+ channel by intracellular GTP.

Authors:  Y Kurachi; H Ito; T Sugimoto
Journal:  Pflugers Arch       Date:  1990-04       Impact factor: 3.657

3.  Guanine nucleotide-binding protein, alpha i-3, directly activates a cation channel in rat renal inner medullary collecting duct cells.

Authors:  D B Light; D A Ausiello; B A Stanton
Journal:  J Clin Invest       Date:  1989-07       Impact factor: 14.808

4.  Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes.

Authors:  N Dascal; N F Lim; W Schreibmayer; W Wang; N Davidson; H A Lester
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-15       Impact factor: 11.205

Review 5.  G proteins: critical control points for transmembrane signals.

Authors:  E J Neer
Journal:  Protein Sci       Date:  1994-01       Impact factor: 6.725

6.  Short-term desensitization of muscarinic K+ current in the heart.

Authors:  Shingo Murakami; Atsushi Inanobe; Yoshihisa Kurachi
Journal:  Biophys J       Date:  2013-09-17       Impact factor: 4.033

7.  Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action.

Authors:  Masaru Ishii; Satoru Fujita; Mitsuhiko Yamada; Yukio Hosaka; Yoshihisa Kurachi
Journal:  Biochem J       Date:  2005-01-01       Impact factor: 3.857

8.  A model of the muscarinic receptor-induced changes in K(+)-current and action potentials in the bullfrog atrial cell.

Authors:  J M Shumaker; J W Clark; W R Giles; G Szabo
Journal:  Biophys J       Date:  1990-03       Impact factor: 4.033

Review 9.  Cell signal control of the G protein-gated potassium channel and its subcellular localization.

Authors:  Yoshihisa Kurachi; Masaru Ishii
Journal:  J Physiol       Date:  2003-08-15       Impact factor: 5.182

10.  Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers.

Authors:  P Kofuji; N Davidson; H A Lester
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-03       Impact factor: 11.205
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