Literature DB >> 2433589

The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.

D E Logothetis, Y Kurachi, J Galper, E J Neer, D E Clapham.   

Abstract

Subunits of guanine nucleotide regulatory proteins purified from bovine cerebral cortex were used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells. Single-channel current measurements unexpectedly indicate that the beta gamma, and not the alpha subunits, are responsible for activating the muscarinic-gated potassium channel.

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Year:  1987        PMID: 2433589     DOI: 10.1038/325321a0

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


  333 in total

1.  Multiple G-protein betagamma combinations produce voltage-dependent inhibition of N-type calcium channels in rat superior cervical ganglion neurons.

Authors:  V Ruiz-Velasco; S R Ikeda
Journal:  J Neurosci       Date:  2000-03-15       Impact factor: 6.167

2.  The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel.

Authors:  J L Leaney; A Tinker
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

3.  Functional expression and FRET analysis of green fluorescent proteins fused to G-protein subunits in rat sympathetic neurons.

Authors:  V Ruiz-Velasco; S R Ikeda
Journal:  J Physiol       Date:  2001-12-15       Impact factor: 5.182

4.  The requirement of presynaptic metabotropic glutamate receptors for the maintenance of locomotion.

Authors:  Michiko Takahashi; Simon Alford
Journal:  J Neurosci       Date:  2002-05-01       Impact factor: 6.167

5.  Differential desensitization of responses mediated by presynaptic and postsynaptic A1 adenosine receptors.

Authors:  Jonathon P Wetherington; Nevin A Lambert
Journal:  J Neurosci       Date:  2002-02-15       Impact factor: 6.167

Review 6.  Controlling potassium channel activities: Interplay between the membrane and intracellular factors.

Authors:  B A Yi; D L Minor; Y F Lin; Y N Jan; L Y Jan
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-25       Impact factor: 11.205

7.  Cloning and characterization of G protein-gated inward rectifier K+ channel (GIRK1) isoforms from heart and brain.

Authors:  L Zhu; X Wu; M B Wu; K W Chan; D E Logothetis; W B Thornhill
Journal:  J Mol Neurosci       Date:  2001-02       Impact factor: 3.444

Review 8.  Heterotrimeric and unconventional GTP binding proteins in plant cell signaling.

Authors:  Sarah M Assmann
Journal:  Plant Cell       Date:  2002       Impact factor: 11.277

9.  Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels.

Authors:  Amy Benians; Joanne L Leaney; Andrew Tinker
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-28       Impact factor: 11.205

10.  The cytosolic GH loop regulates the phosphatidylinositol 4,5-bisphosphate-induced gating kinetics of Kir2 channels.

Authors:  Hai-Long An; Shou-Qin Lü; Jun-Wei Li; Xuan-Yu Meng; Yong Zhan; Meng Cui; Mian Long; Hai-Lin Zhang; Diomedes E Logothetis
Journal:  J Biol Chem       Date:  2012-10-02       Impact factor: 5.157

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