Literature DB >> 24974094

Around LTD hypothesis in motor learning.

Tomoo Hirano1.   

Abstract

Long-term depression (LTD) at parallel fiber-Purkinje neuron synapses has been regarded as a primary cellular mechanism for motor learning. However, this hypothesis has been challenged. Demonstration of normal motor learning under LTD-suppressed conditions suggested that motor learning can occur without LTD. Synaptic plasticity mechanisms other than LTD have been found at various synapses in the cerebellum. Animals may achieve motor learning using several types of synaptic plasticity in the cerebellum including LTD.

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Year:  2014        PMID： 24974094     DOI： 10.1007/s12311-014-0581-4

Source DB:  PubMed          Journal:  Cerebellum        ISSN： 1473-4222            Impact factor:   3.847


  71 in total

1.  Entire course and distinct phases of day-lasting depression of miniature EPSC amplitudes in cultured Purkinje neurons.

Authors:  M Murashima; T Hirano
Journal:  J Neurosci       Date:  1999-09-01       Impact factor: 6.167

2.  Synaptic excitation produces a long-lasting rebound potentiation of inhibitory synaptic signals in cerebellar Purkinje cells.

Authors:  M Kano; U Rexhausen; J Dreessen; A Konnerth
Journal:  Nature       Date:  1992-04-16       Impact factor: 49.962

3.  Differential pre- and postsynaptic mechanisms for synaptic potentiation and depression between a granule cell and a Purkinje cell in rat cerebellar culture.

Authors:  T Hirano
Journal:  Synapse       Date:  1991-04       Impact factor: 2.562

Review 4.  Timing and plasticity in the cerebellum: focus on the granular layer.

Authors:  Egidio D'Angelo; Chris I De Zeeuw
Journal:  Trends Neurosci       Date:  2008-10-30       Impact factor: 13.837

5.  Role of cerebellar cortical protein synthesis in transfer of memory trace of cerebellum-dependent motor learning.

Authors:  Takehito Okamoto; Shogo Endo; Tomoaki Shirao; Soichi Nagao
Journal:  J Neurosci       Date:  2011-06-15       Impact factor: 6.167

6.  Role of granule-cell transmission in memory trace of cerebellum-dependent optokinetic motor learning.

Authors:  Norio Wada; Kazuo Funabiki; Shigetada Nakanishi
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-24       Impact factor: 11.205

7.  Deficient long-term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C beta4 mutant mice.

Authors:  M Miyata; H T Kim; K Hashimoto; T K Lee; S Y Cho; H Jiang; Y Wu; K Jun; D Wu; M Kano; H S Shin
Journal:  Eur J Neurosci       Date:  2001-05       Impact factor: 3.386

8.  Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells.

Authors:  M Ito; M Sakurai; P Tongroach
Journal:  J Physiol       Date:  1982-03       Impact factor: 5.182

9.  Cerebellar Purkinje cell activity drives motor learning.

Authors:  T D Barbara Nguyen-Vu; Rhea R Kimpo; Jacob M Rinaldi; Arunima Kohli; Hongkui Zeng; Karl Deisseroth; Jennifer L Raymond
Journal:  Nat Neurosci       Date:  2013-10-27       Impact factor: 24.884

10.  Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity.

Authors:  Yuichi Kitagawa; Tomoo Hirano; Shin-ya Kawaguchi
Journal:  Mol Syst Biol       Date:  2009-06-16       Impact factor: 11.429
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  4 in total

Review 1.  Oscillations, Timing, Plasticity, and Learning in the Cerebellum.

Authors:  G Cheron; J Márquez-Ruiz; B Dan
Journal:  Cerebellum       Date:  2016-04       Impact factor: 3.847

Review 2.  Depressed by Learning-Heterogeneity of the Plasticity Rules at Parallel Fiber Synapses onto Purkinje Cells.

Authors:  Aparna Suvrathan; Jennifer L Raymond
Journal:  Cerebellum       Date:  2018-12       Impact factor: 3.847

3.  Differential regulations of vestibulo-ocular reflex and optokinetic response by β- and α2-adrenergic receptors in the cerebellar flocculus.

Authors:  Ryo Wakita; Soshi Tanabe; Kazunari Tabei; Asako Funaki; Takuma Inoshita; Tomoo Hirano
Journal:  Sci Rep       Date:  2017-06-21       Impact factor: 4.379

4.  Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRα1 or RET Impairs Normal Cerebellar Motor Learning.

Authors:  Maria Christina Sergaki; Juan Carlos López-Ramos; Stefanos Stagkourakis; Agnès Gruart; Christian Broberger; José María Delgado-García; Carlos F Ibáñez
Journal:  Cell Rep       Date:  2017-06-06       Impact factor: 9.423
  4 in total

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