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Literature DB >> 24162651

Cerebellar Purkinje cell activity drives motor learning.

T D Barbara Nguyen-Vu¹, Rhea R Kimpo, Jacob M Rinaldi, Arunima Kohli, Hongkui Zeng, Karl Deisseroth, Jennifer L Raymond.

Abstract

The climbing fiber input to the cerebellar cortex is thought to provide instructive signals that drive the induction of motor skill learning. We found that optogenetic activation of Purkinje cells, the sole output neurons of the cerebellar cortex, can also drive motor learning in mice. This dual control over the induction of learning by climbing fibers and Purkinje cells can expand the learning capacity of motor circuits.

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Year: 2013 PMID： 24162651 PMCID： PMC3966616 DOI： 10.1038/nn.3576

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

32 in total

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62 in total

Review 1. Motor Learning and the Cerebellum.

Authors: Chris I De Zeeuw; Michiel M Ten Brinke
Journal: Cold Spring Harb Perspect Biol Date: 2015-09-01 Impact factor: 10.005

Cerebellar Purkinje cell activity drives motor learning.

Review 1. Long-term depression.

2. Pairing of pre- and postsynaptic activities in cerebellar Purkinje cells induces long-term changes in synaptic efficacy in vitro.

3. Polarity of long-term synaptic gain change is related to postsynaptic spike firing at a cerebellar inhibitory synapse.

4. Neural learning rules for the vestibulo-ocular reflex.

5. Characterization of Purkinje cells in the goldfish cerebellum during eye movement and adaptive modification of the vestibulo-ocular reflex.

6. Behavior of floccular Purkinje cells correlated with adaptation of vestibulo-ocular reflex in pigmented rabbits.

7. Classical conditioning in rabbits using pontine nucleus stimulation as a conditioned stimulus and inferior olive stimulation as an unconditioned stimulus.

8. Classical conditioning using stimulation of the inferior olive as the unconditioned stimulus.

Review 9. Plasticity in the vestibulo-ocular reflex: a new hypothesis.

10. Role of primate flocculus during rapid behavioral modification of vestibuloocular reflex. I. Purkinje cell activity during visually guided horizontal smooth-pursuit eye movements and passive head rotation.

Review 1. Motor Learning and the Cerebellum.

Review 2. Diversity and dynamism in the cerebellum.

3. Cerebellar encoding of multiple candidate error cues in the service of motor learning.

Review 4. Around LTD hypothesis in motor learning.

5. Signals and learning rules guiding oculomotor plasticity.

6. Abnormal climbing fibre-Purkinje cell synaptic connections in the essential tremor cerebellum.

Review 7. Depressed by Learning-Heterogeneity of the Plasticity Rules at Parallel Fiber Synapses onto Purkinje Cells.

Review 8. Skilled forelimb movements and internal copy motor circuits.

9. Population coding in the cerebellum: a machine learning perspective.

10. Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity.