| Literature DB >> 24972757 |
Xiaofang Hou1, Sicen Wang1, Tao Zhang1, Jing Ma1, Jie Zhang1, Yanmin Zhang1, Wen Lu1, Huaizhen He1, Langchong He2.
Abstract
Traditional Chinese medicines (TCMs) have been used for preventative care for thousands of years. The active components are the basis for the pharmacodynamics of TCMs, and they can be an important source of lead compounds. As a bioaffinity chromatography technique, cell membrane chromatography (CMC) has been developed for almost 20 years since 1996. It has been proven to be a useful method for studying drug-receptor interactions and screening active components from medicinal herbs. In our review in 2007 (Drug Discov. Ther., 1 (2007) 104-107), the preparation, identification, evaluation, and preliminary applications of CMC stationary phases were presented. In this article, we briefly review some of the latest progress and applications about CMC including instrument development, research on drug-receptor interactions, screening active components from TCMs, and quality control of TCMs.Keywords: Active components; Cell membrane chromatography; Drug–receptor interactions; Quality control; Traditional Chinese medicines
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Year: 2014 PMID： 24972757 DOI： 10.1016/j.jpba.2014.05.021
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935