Kelly R Bijanki1, Christopher K Kovach2, Laurie M McCormick3, Hiroto Kawasaki2, Brian J Dlouhy2, Justin Feinstein4, Robert D Jones5, Matthew A Howard2. 1. Department of Psychiatry, University of Iowa Carver College of Medicine, USA. Electronic address: kelly-rowe@uiowa.edu. 2. Department of Neurosurgery, University of Iowa Carver College of Medicine, USA. 3. Department of Psychiatry, University of Iowa Carver College of Medicine, USA. 4. Department of Neurology, University of Iowa Carver College of Medicine, USA; Laureate Institute for Brain Research, USA. 5. Department of Neurology, University of Iowa Carver College of Medicine, USA.
Abstract
BACKGROUND: Sensitive outcome measures are needed to quantify the effects of neuromodulation in mood disorders. OBJECTIVE: This study examined the utility of a novel affective bias (AB) task in identifying transient mood changes induced by amygdala stimulation in a single rare participant. METHODS: Localized, pulsed electrical stimulation was delivered for 8 min during measures of AB and self-reported mood. Responses were compared with those gathered without stimulation on the same day in the same setting, using paired t-tests. RESULTS: Stimulation of the basolateral nucleus of the right amygdala at 50 Hz, 15 V, and 200 μs pulse-width produced a significant positive shift in AB (t = -2.864, df = 53, P = .006), despite equivocal findings on self-reported mood (t = -.184, df = 12, P = .857). CONCLUSION: Affective bias may be more sensitive to stimulation-induced fluctuations in mood than subjective report, suggesting utility as an outcome measure in neuromodulation studies.
BACKGROUND: Sensitive outcome measures are needed to quantify the effects of neuromodulation in mood disorders. OBJECTIVE: This study examined the utility of a novel affective bias (AB) task in identifying transient mood changes induced by amygdala stimulation in a single rare participant. METHODS: Localized, pulsed electrical stimulation was delivered for 8 min during measures of AB and self-reported mood. Responses were compared with those gathered without stimulation on the same day in the same setting, using paired t-tests. RESULTS: Stimulation of the basolateral nucleus of the right amygdala at 50 Hz, 15 V, and 200 μs pulse-width produced a significant positive shift in AB (t = -2.864, df = 53, P = .006), despite equivocal findings on self-reported mood (t = -.184, df = 12, P = .857). CONCLUSION: Affective bias may be more sensitive to stimulation-induced fluctuations in mood than subjective report, suggesting utility as an outcome measure in neuromodulation studies.
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