| Literature DB >> 15177442 |
Jeffrey A McKie1, Shripad S Bhagwat, Helen Brady, Mary Doubleday, Leah Gayo, Mathew Hickman, Ravi K Jalluri, Sak Khammungkhune, Adam Kois, Deborah Mortensen, Normand Richard, John Sapienza, Graziella Shevlin, Bernd Stein, May Sutherland.
Abstract
Starting from a phenol screening hit (6), three series of benzopyranone selective estrogen receptor modulators (SERMs) have been designed, synthesized, and analyzed for both estrogen receptor alpha binding affinity and in vitro activity in two cell assays. The lead compound identified, SP500263 (13), was more potent than raloxifene and tamoxifen in a cell-based assay measuring inhibition of interleukin-6 release.Entities:
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Year: 2004 PMID： 15177442 DOI： 10.1016/j.bmcl.2004.04.081
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823