Literature DB >> 2497028

Abnormal tau species are produced during Alzheimer's disease neurodegenerating process.

S Flament1, A Delacourte.   

Abstract

Tau proteins were detected in human brain using two polyclonal antibodies: anti-paired helical filaments and anti-human native tau proteins. Both antisera detected identically the normal set of tau proteins in control brains. Moreover they detected two abnormal tau variants of 64 and 69 kDa exclusively in brain areas showing neurofibrillary tangles and senile plaques. Tau 64 and 69 were abnormally phosphorylated as revealed by the decrease in their molecular mass observed after alkaline phosphatase treatment. Therefore, tau 64 and 69 are specific markers of the neurofibrillary degeneration of the Alzheimer type and might be useful tools for studying the first pathological events that lead to neuronal death.

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Year:  1989        PMID： 2497028     DOI： 10.1016/0014-5793(89)81337-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  19 in total

1.  Massive accumulation of modified tau and severe depletion of normal tau characterize the cerebral cortex and white matter of Alzheimer's disease. Demonstration using the hydrated autoclaving method.

Authors:  R W Shin; T Iwaki; T Kitamoto; Y Sato; J Tateishi
Journal:  Am J Pathol       Date:  1992-04       Impact factor: 4.307

Review 2.  Tau pathology generated by overexpression of tau.

Authors:  I Grundke-Iqbal; K Iqbal
Journal:  Am J Pathol       Date:  1999-12       Impact factor: 4.307

3.  Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease.

Authors:  M G Spillantini; M Goedert; R Jakes; A Klug
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

Review 4.  Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease.

Authors:  K Iqbal; I Grundke-Iqbal
Journal:  Mol Neurobiol       Date:  1991       Impact factor: 5.590

5.  Correlation between microscopical changes and Tau 64 and 69 biochemical detection in senile dementia of the Alzheimer type. Tau 64 and 69 are reliable markers of the neurofibrillary degeneration.

Authors:  S Flament; A Delacourte; P Delaère; C Duyckaerts; J J Hauw
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

6.  Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease. Demonstration with a panel of antibodies against Tau proteins.

Authors:  A Delacourte; S Flament; E M Dibe; P Hublau; B Sablonnière; B Hémon; V Shérrer; A Défossez
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

7.  Tau phosphorylation sites work in concert to promote neurotoxicity in vivo.

Authors:  Michelle L Steinhilb; Dora Dias-Santagata; Tudor A Fulga; Daniel L Felch; Mel B Feany
Journal:  Mol Biol Cell       Date:  2007-10-10       Impact factor: 4.138

8.  Expression and phosphorylation of a three-repeat isoform of tau in transfected non-neuronal cells.

Authors:  J M Gallo; D P Hanger; E C Twist; K S Kosik; B H Anderton
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

Review 9.  Mechanism of Alzheimer's disease: arguments for a neurotransmitter-aluminium complex implication.

Authors:  R Deloncle; O Guillard
Journal:  Neurochem Res       Date:  1990-12       Impact factor: 3.996

10.  Immunohistochemical and histopathologic correlates of Alzheimer's disease-associated Alz-50 immunoreactivity quantified in homogenates of cerebral tissue.

Authors:  S M de la Monte; R A Spratt; J Chong; H A Ghanbari; J R Wands
Journal:  Am J Pathol       Date:  1992-12       Impact factor: 4.307
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