Jung Jae Park1, Chan Kyo Kim2, Sung Yoon Park3, Arjan W Simonetti4, EunJu Kim5, Byung Kwan Park1, Seung Jae Huh6. 1. Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 2. Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: chankyokim@skku.edu. 3. Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. 4. MR Clinical Science, Philips Healthcare, Best, Netherlands. 5. Philips Healthcare Korea, Seoul, Republic of Korea; Graduate school of Biomedical Science and Engineering, Hanyang University, Seoul, Republic of Korea. 6. Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Abstract
PURPOSE: To investigate diffusion-weighted (DWI) and dynamic contrast-enhanced MR imaging (DCE-MRI) as early response predictors in cervical cancer patients who received concurrent chemoradiotherapy (CCRT). MATERIALS AND METHODS: Sixteen patients with cervical cancer underwent DWI and DCE-MRI before CCRT (preTx), at 1week (postT1) and 4weeks (postT2) after initiating treatment, and 1month after the end of treatment (postT3). At each point, apparent diffusion coefficient (ADC) and DCE-MRI parameters were measured in tumors and gluteus muscles (GM). Tumor response was correlated with imaging parameters or changes in imaging parameters at each point. RESULTS: At each point, ADC, K(trans) and Ve in tumors showed significant changes (P<0.05), as compared with those of GM (P>0.05). PostT1 tumor ADCs showed a significant correlation with tumor size response at postT2 (P=0.041), and changes in tumor ADCs at postT1 had a significant correlation with tumor size (P=0.04) and volume response (P=0.003) at postT2. In tumors, preTx K(trans) and Ve showed significant correlations with tumor size at postT3 (P=0.011) and tumor size response at postT2 (P=0.019), respectively. CONCLUSION: DWI and DCE-MRI, as early biomarkers, have the potential to evaluate therapeutic responses to CCRT in cervical cancers.
PURPOSE: To investigate diffusion-weighted (DWI) and dynamic contrast-enhanced MR imaging (DCE-MRI) as early response predictors in cervical cancerpatients who received concurrent chemoradiotherapy (CCRT). MATERIALS AND METHODS: Sixteen patients with cervical cancer underwent DWI and DCE-MRI before CCRT (preTx), at 1week (postT1) and 4weeks (postT2) after initiating treatment, and 1month after the end of treatment (postT3). At each point, apparent diffusion coefficient (ADC) and DCE-MRI parameters were measured in tumors and gluteus muscles (GM). Tumor response was correlated with imaging parameters or changes in imaging parameters at each point. RESULTS: At each point, ADC, K(trans) and Ve in tumors showed significant changes (P<0.05), as compared with those of GM (P>0.05). PostT1 tumor ADCs showed a significant correlation with tumor size response at postT2 (P=0.041), and changes in tumor ADCs at postT1 had a significant correlation with tumor size (P=0.04) and volume response (P=0.003) at postT2. In tumors, preTx K(trans) and Ve showed significant correlations with tumor size at postT3 (P=0.011) and tumor size response at postT2 (P=0.019), respectively. CONCLUSION: DWI and DCE-MRI, as early biomarkers, have the potential to evaluate therapeutic responses to CCRT in cervical cancers.
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