Hypolipidemic effect of oryzanol concentrate and low temperature extracted crude rice bran oil in experimental male wistar rats.

Blends of refined groundnut oil (GNO) and oryzanol concentrate having 3, 5, and 10% oryzanol in the blend, and a rice bran oil (RBO) which had retained all the nutrients such as oryzanol, tocopherols and tocotrienols and the unsaponifiable matter components of crude oil (GWF RBO) were prepared. Weanling rats were fed with diet containing the oil blends/rice bran oil at 10% level for 60 days and then dissected. The lipid profiles in serum, liver were investigated and the cholesterol levels were marginally reduced (7-16% in serum, 10-14.5% in liver) in rats fed oryzanol containing diet. RBO, GWF RBO containing diets showed a reduction of serum cholesterol by 14%, 15% respectively when compared to those fed with GNO. Serum and liver lipid analysis also showed significant change in TG concentration in rats fed blended oils containing oryzanol compared to the rats given GNO. Histology of liver and kidneys did not show changes. These studies indicated that oryzanol has an effect in lowering serum and liver cholesterol and shows antiatherogenic properties when incorporated into groundnut oil.