Prashanthi Chippagiri1, Ali Im2, Spoorthi Ravi Banavar3. 1. Senior Lecturer, Department of Oral Medicine, M.S.Ramaiah Dental College and Hospital , Bangalore, Karnataka, India . 2. Professor, Department of Oral Medicine, College of Dental Sciences , Davangere, Karnataka, India . 3. Reader, Department of Oral Pathology, M.S.Ramaiah Dental College and Hospital , Bangalore, Karnataka, India .
Abstract
CONTEXT: Oral squamous cell carcinoma (OSCC) is the most common cancer of the head and neck. It accounts for more than 90% of all malignancies Which occur in the head and neck region. The high incidence and mortality rate of oral cancer stimulates continuation of research on finding new diagnostic tools or markers for it. AIM: To evaluate the possible role of serum β-carotene as a biochemical parameter in the diagnosis of oral squamous cell carcinoma. MATERIALS AND METHODS: The serumβ-carotene levels in 40 patients with clinically diagnosed and histopathologically confirmed oral squamous cell carcinoma were estimated and the levels were compared with those of 40 healthy controls. The serum β-carotene levels were estimated by using a spectrophotometer. The data which was obtained was analyzed statistically by using unpaired t-test. RESULTS: Subjects with oral squamous cell carcinoma showed significantly lower levels of mean serum β-carotene (149.95 ± 61.29) as compared to those seen in controls (278.19 ± 90.12). CONCLUSION: The results of the present study are encouraging and they suggest that the estimation of the low levels of β-carotene in the patients with oral squamous cell carcinoma may be a useful diagnostic tool for making the diagnosis of oral squamous Cell carcinoma and thereby improving the prognosis of this dreaded disease.
CONTEXT: Oral squamous cell carcinoma (OSCC) is the most common cancer of the head and neck. It accounts for more than 90% of all malignancies Which occur in the head and neck region. The high incidence and mortality rate of oral cancer stimulates continuation of research on finding new diagnostic tools or markers for it. AIM: To evaluate the possible role of serum β-carotene as a biochemical parameter in the diagnosis of oral squamous cell carcinoma. MATERIALS AND METHODS: The serumβ-carotene levels in 40 patients with clinically diagnosed and histopathologically confirmed oral squamous cell carcinoma were estimated and the levels were compared with those of 40 healthy controls. The serum β-carotene levels were estimated by using a spectrophotometer. The data which was obtained was analyzed statistically by using unpaired t-test. RESULTS: Subjects with oral squamous cell carcinoma showed significantly lower levels of mean serum β-carotene (149.95 ± 61.29) as compared to those seen in controls (278.19 ± 90.12). CONCLUSION: The results of the present study are encouraging and they suggest that the estimation of the low levels of β-carotene in the patients with oral squamous cell carcinoma may be a useful diagnostic tool for making the diagnosis of oral squamous Cell carcinoma and thereby improving the prognosis of this dreaded disease.
Authors: Samantha Lang; Sarah Schimansky; Rhona Beynon; Christopher Penfold; Amy Davies; Andrea Waylen; Steven Thomas; Miranda Pring; Michael Pawlita; Tim Waterboer; Andrew R Ness Journal: Head Neck Date: 2019-01-30 Impact factor: 3.147
Authors: Vlad Moisoiu; Andrei Stefancu; Diana Gulei; Radu Boitor; Lorand Magdo; Lajos Raduly; Sergiu Pasca; Paul Kubelac; Nikolay Mehterov; Vasile Chiș; Marioara Simon; Mihai Muresan; Alexandra Iulia Irimie; Mihaela Baciut; Rares Stiufiuc; Ioana E Pavel; Patriciu Achimas-Cadariu; Calin Ionescu; Vladimir Lazar; Victoria Sarafian; Ioan Notingher; Nicolae Leopold; Ioana Berindan-Neagoe Journal: Int J Nanomedicine Date: 2019-08-02