Renu Dhasmana1, I P Singh2, Ramesh C Nagpal3. 1. Associate Professor, Department of Ophthalmology, Himalayan Institute of Medical Science , Dehradun, India . 2. Consultant, Dr. K.P.'s Eye Care Centre , Manimajra, Chandigarh-160101, India . 3. Professor, Department of Ophthalmology, Himalayan Institute of Medical Science , Dehradun, India .
Abstract
BACKGROUND: Diabetics have abnormal corneal morphology along with higher rate of corneal endothelial cell loss and decreased corneal endothelial cell density and early onset of cataract. AIM: To evaluate the changes in corneal endothelium and corneal thickness in patients with diabetes mellitus after Manual Small Incision Cataract Surgery (MSICS) in eyes with brunescent Cataract. MATERIALS AND METHODS: Sixty eyes of 60 patients with Type 2 diabetes mellitus and 60 eyes of 60 age matched healthy patients of advanced brunescent cataract underwent MSICS were evaluated. All the patients underwent specular microscopy for the corneal endothelial cell count of cornea and central corneal thickness pre-operatively, at one week, six weeks and 12 weeks post-operatively. The morphology, variation in the endothelial size and shape and percentage of hexagonal cells were assessed. RESULTS: The mean pre-operative endothelial count in the control was higher than the diabetic group (p<0.001). The post-operative endothelial count loss in both the groups were statistically significant (one-way ANOVA p<0.001). On comparing post-operative endothelial loss in non diabetics (8.05%) to diabetic group, the diabetic group had significantly higher endothelial loss (14.19% p<0.001). There was also a significant increase in central corneal thickness in diabetics as compared to control (p = 0.004). The change in percentage hexagon cells in diabetic group was significantly higher than in non diabetic group (p = 0.005). Inter group change in coefficient of variance was not statistically significant (p=0.144). CONCLUSION: Compared to non-diabetic patients, diabetic patients have more endothelial cells damage after MSICS. Corneal endothelial evaluation of diabetic patients is recommended before any intraocular surgery.
BACKGROUND:Diabetics have abnormal corneal morphology along with higher rate of corneal endothelial cell loss and decreased corneal endothelial cell density and early onset of cataract. AIM: To evaluate the changes in corneal endothelium and corneal thickness in patients with diabetes mellitus after Manual Small Incision Cataract Surgery (MSICS) in eyes with brunescent Cataract. MATERIALS AND METHODS: Sixty eyes of 60 patients with Type 2 diabetes mellitus and 60 eyes of 60 age matched healthy patients of advanced brunescent cataract underwent MSICS were evaluated. All the patients underwent specular microscopy for the corneal endothelial cell count of cornea and central corneal thickness pre-operatively, at one week, six weeks and 12 weeks post-operatively. The morphology, variation in the endothelial size and shape and percentage of hexagonal cells were assessed. RESULTS: The mean pre-operative endothelial count in the control was higher than the diabetic group (p<0.001). The post-operative endothelial count loss in both the groups were statistically significant (one-way ANOVA p<0.001). On comparing post-operative endothelial loss in non diabetics (8.05%) to diabetic group, the diabetic group had significantly higher endothelial loss (14.19% p<0.001). There was also a significant increase in central corneal thickness in diabetics as compared to control (p = 0.004). The change in percentage hexagon cells in diabetic group was significantly higher than in non diabetic group (p = 0.005). Inter group change in coefficient of variance was not statistically significant (p=0.144). CONCLUSION: Compared to non-diabeticpatients, diabeticpatients have more endothelial cells damage after MSICS. Corneal endothelial evaluation of diabeticpatients is recommended before any intraocular surgery.
Entities:
Keywords:
Central corneal thickness; Corneal endothelium
Authors: Ruchi Shah; Cynthia Amador; Kati Tormanen; Sean Ghiam; Mehrnoosh Saghizadeh; Vaithi Arumugaswami; Ashok Kumar; Andrei A Kramerov; Alexander V Ljubimov Journal: Exp Eye Res Date: 2021-01-21 Impact factor: 3.467
Authors: Konstantinos T Tsaousis; Dimitrios Z Panagiotou; Eirini Kostopoulou; Vasileios Vlatsios; Despoina Stampouli Journal: Ann Med Surg (Lond) Date: 2015-12-19