T S Gugapriya1, S Karthick2, B Nagarjuna3. 1. Associate Professor, Department of Anatomy, Chennai Medical College Hospital and Research Centre , Trichy, India . 2. Assistant Professor, Department of Anatomy, Melmaruvathur Adiparasakthi Institute of Medical Sciences and Research , Melmaruvathur, India . 3. III Year Medical Student, Department of Anatomy, Melmaruvathur Adiparasakthi Institute of Medical Sciences and Research , Melmaruvathur, India .
Abstract
INTRODUCTION: Diabetes mellitus (DM) is one of the metabolic syndromes prevalent worldwide, with more concentration in the Asian region. Many studies have been conducted in order to understand the complex pathogenesis of this disease. Yet, there exists a lacuna in our knowledge about DM. This study aims at establishing the reason for glycemic variation in menstruating Type-2 diabetic women by estimation of C-reactive protein, an inflammatory marker that exhibits significant association with changes in blood glucose levels. METHODOLOGY: A prospective study was undertaken in Type-2 diabetic women of reproductive age group to assess the variability of glycemic control during different phases of menstrual cycle using high sensitivity C reactive protein (hs-CRP) as the biomarker. Fifty women were enrolled after satisfying a set of inclusion and exclusion criteria. The fasting blood glucose, hs-CRP concentration and endogenous female hormones were assayed in follicular and luteal phases of the cycle. The observed parameters were analyzed statistically for significant correlation. Observation and Result: The result showed that hs-CRP level significantly correlates with increasing levels of fasting blood glucose level in both the phases of menstrual cycle in Type-2 diabetic women. The significance is statistically stronger during luteal phase of the cycle (r = 0.807; p<0.05). The correlation observed between hs-CRP and Estrodiol in follicular phase (r = -0.311; p < 0.05) was not statistically significant. The hs-CRP level increased significantly with progesterone level during luteal phase (r = 0.826; p <0.05). CONCLUSION: This study concludes that Type-2 diabetic women of reproductive age group encounter a period of poor glycemic control during luteal phase, as shown by statistically high hs-CRP level mediated by endogenous progesterone hormone. Therefore, this study advocates careful monitoring, life style adjustments and drug regime to reduce the fluctuation in glycemic level experienced by Type-2 diabetic premenopausal women in the luteal phase.
INTRODUCTION:Diabetes mellitus (DM) is one of the metabolic syndromes prevalent worldwide, with more concentration in the Asian region. Many studies have been conducted in order to understand the complex pathogenesis of this disease. Yet, there exists a lacuna in our knowledge about DM. This study aims at establishing the reason for glycemic variation in menstruating Type-2 diabeticwomen by estimation of C-reactive protein, an inflammatory marker that exhibits significant association with changes in blood glucose levels. METHODOLOGY: A prospective study was undertaken in Type-2 diabeticwomen of reproductive age group to assess the variability of glycemic control during different phases of menstrual cycle using high sensitivity C reactive protein (hs-CRP) as the biomarker. Fifty women were enrolled after satisfying a set of inclusion and exclusion criteria. The fasting blood glucose, hs-CRP concentration and endogenous female hormones were assayed in follicular and luteal phases of the cycle. The observed parameters were analyzed statistically for significant correlation. Observation and Result: The result showed that hs-CRP level significantly correlates with increasing levels of fasting blood glucose level in both the phases of menstrual cycle in Type-2 diabeticwomen. The significance is statistically stronger during luteal phase of the cycle (r = 0.807; p<0.05). The correlation observed between hs-CRP and Estrodiol in follicular phase (r = -0.311; p < 0.05) was not statistically significant. The hs-CRP level increased significantly with progesterone level during luteal phase (r = 0.826; p <0.05). CONCLUSION: This study concludes that Type-2 diabeticwomen of reproductive age group encounter a period of poor glycemic control during luteal phase, as shown by statistically high hs-CRP level mediated by endogenous progesterone hormone. Therefore, this study advocates careful monitoring, life style adjustments and drug regime to reduce the fluctuation in glycemic level experienced by Type-2 diabetic premenopausal women in the luteal phase.
Authors: Claudine A Blum; Beat Müller; Peter Huber; Marius Kraenzlin; Christian Schindler; Christian De Geyter; Ulrich Keller; Jardena J Puder Journal: J Clin Endocrinol Metab Date: 2005-03-29 Impact factor: 5.958
Authors: C F Draper; K Duisters; B Weger; A Chakrabarti; A C Harms; L Brennan; T Hankemeier; L Goulet; T Konz; F P Martin; S Moco; J van der Greef Journal: Sci Rep Date: 2018-10-01 Impact factor: 4.379