Yuji Tajiri1, Kazuo Mimura, Fumio Umeda. 1. Endocrinology and Metabolism Division, Fukuoka Medical Association Hospital, Fukuoka 814-8522, Japan. tajiri@seijin.city.fukuoka.med.or.jp
Abstract
OBJECTIVE: To assess the relationship between high-sensitivity (HS) C-reactive protein (CRP) and metabolic syndrome (MetS) or atherosclerosis and to assess effects of strict metabolic control on the degree of inflammation and MetS in patients with type 2 diabetes. RESEARCH METHODS AND PROCEDURES: Four hundred thirteen patients with diabetes were enrolled in the cross-sectional study. Of these 413 patients, 161 patients were further admitted for 2.4 +/- 0.4 weeks (mean +/- SD) to investigate the change in HS-CRP or other parameters under strict metabolic control. RESULTS: Log-transformed HS-CRP value (log HS-CRP) was strongly correlated with BMI (r = 0.448, p < 0.01). Log HS-CRP was also correlated with the presence of MetS or each component of MetS. Furthermore, a positive significant trend in HS-CRP levels was shown with an increasing number of MetS components (p < 0.05). Log HS-CRP showed a significant positive correlation with carotid artery intima-media thickness (IMT) (r = 0.152, p < 0.01). In multiple step-wise regression analysis, BMI, hemoglobin A(1c), right IMT, duration of diabetes, and triglyceride were selected as explanatory variables for log HS-CRP (R2 = 0.412). Under strict metabolic control, HS-CRP was significantly (p < 0.01) lower, together with lower levels of other markers for MetS. The change in HS-CRP was significantly correlated with the change in BMI (r = 0.161, p = 0.04). DISCUSSION: In subjects with type 2 diabetes, HS-CRP levels are related to MetS and subclinical atherosclerosis. Strict weight management and metabolic control were associated with a reduction in HS-CRP levels, and changes in HS-CRP were related to changes in weight, supporting the hypothesis that lifestyle modification reduces inflammation and the risk of CHD.
OBJECTIVE: To assess the relationship between high-sensitivity (HS) C-reactive protein (CRP) and metabolic syndrome (MetS) or atherosclerosis and to assess effects of strict metabolic control on the degree of inflammation and MetS in patients with type 2 diabetes. RESEARCH METHODS AND PROCEDURES: Four hundred thirteen patients with diabetes were enrolled in the cross-sectional study. Of these 413 patients, 161 patients were further admitted for 2.4 +/- 0.4 weeks (mean +/- SD) to investigate the change in HS-CRP or other parameters under strict metabolic control. RESULTS: Log-transformed HS-CRP value (log HS-CRP) was strongly correlated with BMI (r = 0.448, p < 0.01). Log HS-CRP was also correlated with the presence of MetS or each component of MetS. Furthermore, a positive significant trend in HS-CRP levels was shown with an increasing number of MetS components (p < 0.05). Log HS-CRP showed a significant positive correlation with carotid artery intima-media thickness (IMT) (r = 0.152, p < 0.01). In multiple step-wise regression analysis, BMI, hemoglobin A(1c), right IMT, duration of diabetes, and triglyceride were selected as explanatory variables for log HS-CRP (R2 = 0.412). Under strict metabolic control, HS-CRP was significantly (p < 0.01) lower, together with lower levels of other markers for MetS. The change in HS-CRP was significantly correlated with the change in BMI (r = 0.161, p = 0.04). DISCUSSION: In subjects with type 2 diabetes, HS-CRP levels are related to MetS and subclinical atherosclerosis. Strict weight management and metabolic control were associated with a reduction in HS-CRP levels, and changes in HS-CRP were related to changes in weight, supporting the hypothesis that lifestyle modification reduces inflammation and the risk of CHD.