Literature DB >> 24958191

Clusterin variants are not associated with southern Chinese patients with Alzheimer's disease.

Shen-Ji Lu1, Hong-Lei Li1, Yi-Min Sun1, Zhi-Jun Liu1, Ping Yang1, Zhi-Ying Wu2.   

Abstract

Recent genome-wide association studies identified clusterin (CLU) to be associated with sporadic Alzheimer's disease. To help clarify the relevance of CLU as genetic determinant of AD, we analyzed its association in southern Chinese Han population. This study comprised 499 sporadic Alzheimer's disease patients and 592 unrelated age- and sex-matched healthy controls. Four single-nucleotide polymorphisms (rs2279590, rs9331888, rs11136000, and rs1532278) within CLU were selected for genotyping. No positive association was found between the CLU variants and AD. Our study suggests that CLU variants may not be an AD susceptibility factor in southern Chinese Han population.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alzheimer's disease; Association; CLU; Chinese

Mesh：

Substances：

Year:  2014        PMID： 24958191     DOI： 10.1016/j.neurobiolaging.2014.05.015

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  8 in total

1.  CLU rs9331888 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Caucasian But Not East Asian Populations.

Authors:  Shuyan Zhang; Xuling Li; Guoda Ma; Yongshuai Jiang; Mingzhi Liao; Rennan Feng; Liangcai Zhang; Jiafeng Liu; Guangyu Wang; Bin Zhao; Qinghua Jiang; Keshen Li; Guiyou Liu
Journal:  Mol Neurobiol       Date:  2015-01-30       Impact factor: 5.590

Review 2.  Correlation of rs9331888 polymorphism with Alzheimer's disease among Caucasian and Chinese populations: a meta-analysis and systematic review.

Authors:  Bin Zhu; Rui Min Wang; Jian Ting Wang; Rui Ling Chen; Yan Fei Zheng; Lei Zhang; Zhi Gang Zhao
Journal:  Metab Brain Dis       Date:  2017-02-06       Impact factor: 3.584

Review 3.  Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine.

Authors:  Aseel Eid; Isha Mhatre; Jason R Richardson
Journal:  Pharmacol Ther       Date:  2019-03-12       Impact factor: 12.310

4.  Association between CLU gene rs11136000 polymorphism and Alzheimer's disease: an updated meta-analysis.

Authors:  Ruixia Zhu; Xu Liu; Zhiyi He
Journal:  Neurol Sci       Date:  2018-02-02       Impact factor: 3.307

5.  Association between clusterin concentration and dementia: a systematic review and meta-analysis.

Authors:  Caiping Yang; Hai Wang; Chaojiu Li; Huiyan Niu; Shunkui Luo; Xingzhi Guo
Journal:  Metab Brain Dis       Date:  2018-10-05       Impact factor: 3.584

6.  Association between clusterin gene polymorphism rs11136000 and late-onset Alzheimer's disease susceptibility: A review and meta-analysis of case-control studies.

Authors:  Wenjin Du; Jiping Tan; Wei Xu; Jinwen Chen; Luning Wang
Journal:  Exp Ther Med       Date:  2016-09-21       Impact factor: 2.447

7.  Analyzing 74,248 Samples Confirms the Association Between CLU rs11136000 Polymorphism and Alzheimer's Disease in Caucasian But Not Chinese population.

Authors:  Zhijie Han; Jiaojiao Qu; Jiehong Zhao; Xiao Zou
Journal:  Sci Rep       Date:  2018-07-23       Impact factor: 4.379

8.  BIN1 rs744373 variant shows different association with Alzheimer's disease in Caucasian and Asian populations.

Authors:  Zhifa Han; Tao Wang; Rui Tian; Wenyang Zhou; Pingping Wang; Peng Ren; Jian Zong; Yang Hu; Shuilin Jin; Qinghua Jiang
Journal:  BMC Bioinformatics       Date:  2019-12-24       Impact factor: 3.169
  8 in total

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