Literature DB >> 24957826

Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa.

Emanuela Frangipani1, Carlo Bonchi1, Fabrizia Minandri1, Francesco Imperi2, Paolo Visca3.   

Abstract

Gallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)3 in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24957826      PMCID： PMC4135843          DOI： 10.1128/AAC.03154-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

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3.  Isolation of an iron-binding compound from Pseudomonas aeruginosa.

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Authors:  Karla D Krewulak; Hans J Vogel
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  19 in total

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7.  Gallium-Protoporphyrin IX Inhibits Pseudomonas aeruginosa Growth by Targeting Cytochromes.

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8.  Pyoverdine Inhibitors and Gallium Nitrate Synergistically Affect Pseudomonas aeruginosa.

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9.  Drug repurposing as an alternative for the treatment of recalcitrant bacterial infections.

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