Literature DB >> 24956555

Synthesis of new class of spirocarbocycle derivatives by multicomponent domino reaction and their evaluation for antimicrobial, anticancer activity and molecular docking studies.

N Sudhapriya1, P T Perumal2, C Balachandran3, S Ignacimuthu3, M Sangeetha4, Mukesh Doble4.   

Abstract

A series of 25 new spirocarbocycles were synthesized by a three component reaction that involves few cyclic nucleophiles, vinyl malononitriles and aldehydes with variable substitution patterns. All the synthesized compounds were evaluated for their antimicrobial activity and the compounds showed significant activity. Synthesized compounds 4c, 4i and 6i showed good anticancer activity against A549 cancer cell line. Molecular docking studies indicated that compound 4i had the greatest affinity for DNA gyrase receptor than others and compound 6i had the greatest affinity for anaplastic lymphoma kinase (ALK) receptor. These compounds can be better therapeutic agents for microbial and cancer cell lines.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Anticancer activity; Antimicrobial activity; Molecular docking; Multicomponent reaction; Spirocarbocycle; Vinylogous Michael addition

Mesh：

Substances：

Year:  2014        PMID： 24956555     DOI： 10.1016/j.ejmech.2014.05.065

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  5 in total

1.  Novel Anticancer Fused Pyrazole Derivatives as EGFR and VEGFR-2 Dual TK Inhibitors.

Authors:  Nashwa M Saleh; Marwa G El-Gazzar; Hala M Aly; Rana A Othman
Journal:  Front Chem       Date:  2020-01-24       Impact factor: 5.221

Review 2.  Synthesis of Biologically Active Molecules through Multicomponent Reactions.

Authors:  Daniel Insuasty; Juan Castillo; Diana Becerra; Hugo Rojas; Rodrigo Abonia
Journal:  Molecules       Date:  2020-01-24       Impact factor: 4.411

3.  Crystal structure of 8-[7,8-bis-(4-chloro-benzo-yl)-7H-cyclo-penta-[a]ace-naphthylen-9-yl]naphthalene-1-carb-oxy-lic acid.

Authors:  Jomon P Jacob; M Sithambaresan; Christy Kunjachan; M R Prathapachandra Kurup
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-01-01

4.  Supported l-tryptophan on Fe3O4@SiO2 as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2'-naphthalene]-4'-carbonitrile derivatives.

Authors:  Aref Ghasemi-Ghahsareh; Javad Safaei-Ghomi; Hourieh Sadat Oboudatian
Journal:  RSC Adv       Date:  2022-01-05       Impact factor: 3.361

5.  One-Pot Multicomponent Synthesis and Bioevaluation of Tetrahydroquinoline Derivatives as Potential Antioxidants, α-Amylase Enzyme Inhibitors, Anti-Cancerous and Anti-Inflammatory Agents.

Authors:  Samra Farooq; Aqsa Mazhar; Areej Ghouri; Naseem Ullah
Journal:  Molecules       Date:  2020-06-11       Impact factor: 4.411
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.