Literature DB >> 24955176

Synthesis and effects of new caffeic acid derivatives on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages.

Jie Zhang1, Liu-Xin Xu1, Xu-Sheng Xu1, Bo-Wei Li1, Rui Wang1, Jian-Jun Fu1.   

Abstract

In this study, 20 new derivatives of caffeic acid esters were synthesized and their inhibitory activities against the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages were determined. Compounds 3l, 3r, 3s and 3t were found to decrease nitrite levels in a dose-dependent manner in LPS-induced cells and showed potent inhibitory activities against the NO production in RAW264.7 macrophages with IC50 values of 7.4, 5.9, 3.3 and 2.2 μM, respectively. They could be selected as compromising compounds for the later pharmacological study.

Entities:  

Keywords:  Caffeic acid; anti-inflammatory; condensation; nitric oxide; structure modification

Year:  2014        PMID： 24955176      PMCID： PMC4057855     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  11 in total

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