| Literature DB >> 33772326 |
Carlos Arterio Sorgi1, Giuliana de Campos Chaves Lamarque2, Maraisa P Verri3, Paulo Nelson-Filho2, Lúcia Helena Faccioli3, Francisco Wanderley Garcia Paula-Silva4,5.
Abstract
The aim of the present study was to investigate the effects of caffeic acid in the interface between the antimicrobial and anti-inflammatory function in macrophage response against S. mutans. S. mutans (108 cfu/mL) were incubated with caffeic acid to determinate the half-maximal inhibitory concentration (IC50) and macrophage cells were incubated with caffeic acid to determinate cell viability and toxicity. Anti-inflammatory effects were measured by nitrite accumulation, TNF-α and PGE2 production, and NF-kB phosphorylation, and S. mutans survival following internalization by macrophages was investigated. We found that caffeic acid presented antimicrobial activity against S. mutans (IC50 = 2.938 ± 0.1225 mM) without exerting cytotoxicity. Caffeic acid inhibited nitrite, TNF-α and PGE2 production by the NF-kB dependent pathway, indicating an immunomodulatory property. Caffeic acid also contributed to macrophage bacteria clearance activity. In summary, caffeic acid presented antimicrobial activity against S. mutans and anti-inflammatory effects in macrophages.Entities:
Keywords: Anti-inflammatory; Caffeic acid; Cytokine; Macrophage; Streptococcus mutans
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Year: 2021 PMID： 33772326 DOI： 10.1007/s00203-021-02290-x
Source DB: PubMed Journal: Arch Microbiol ISSN： 0302-8933 Impact factor: 2.552