Literature DB >> 24955171

Tempol protects human lymphocytes from genotoxicity induced by cisplatin.

Omar F Khabour1, Karem H Alzoubi2, Doa'a S Mfady1, Mohammed Alasseiri1, Taghrid F Hasheesh1.   

Abstract

The use of cisplatin in treatments of human malignancies is limited by its side effects that include DNA damage and the subsequent risk of developing secondary cancer. In this study, we examined the possible protective effect of Tempol against DNA damage induced by cisplatin in human lymphocytes using chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) assays. Cisplatin induced significant elevation in the frequencies of CAs and SCEs in cultured human lymphocytes (P < 0.01). Treatment of lymphocytes with Tempol significantly lowered CAs and SCEs induced by cisplatin. Tempol alone did not affect spontaneous levels of SCEs and CAs observed in the control group (P > 0.05). In conclusion, Tempol protects human lymphocytes against genotoxicity induced by the anticancer drug cisplatin.

Entities:  

Keywords:  Cisplatin; Tempol; chromosomal aberrations; oxidative stress; sister chromatid exchanges

Year:  2014        PMID： 24955171      PMCID： PMC4057850     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  54 in total

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2.  Prevention of γ-radiation induced cellular genotoxicity by tempol: protection of hematopoietic system.

Authors:  Lakshmy Ramachandran; Cherupally Krishnan Krishnan Nair
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3.  Assessment of DNA damage using chromosomal aberrations assay in lymphocytes of waterpipe smokers.

Authors:  Enas S Alsatari; Mohammad Azab; Omar F Khabour; Karem H Alzoubi; May F Sadiq
Journal:  Int J Occup Med Environ Health       Date:  2012-06-22       Impact factor: 1.843

4.  Evaluation of the genotoxicity of cisplatin, paclitaxel and 5-fluorouracil combined treatment in the Drosophila wing-spot test.

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Journal:  Food Chem Toxicol       Date:  2010-08-18       Impact factor: 6.023

5.  Evaluation of curcumin and cisplatin-induced DNA damage in PC12 cells by the alkaline comet assay.

Authors:  Leonardo Meneghin Mendonça; Graciela Cristina dos Santos; Raquel Alves dos Santos; Catarina Satie Takahashi; Maria de Lourdes Pires Bianchi; Lusânia Maria Greggi Antunes
Journal:  Hum Exp Toxicol       Date:  2010-01-05       Impact factor: 2.903

6.  Genotoxic and antigenotoxic effects of Hemidesmus indicus R. Br. root extract in cultured lymphocytes.

Authors:  R Ananthi; N Chandra; S T Santhiya; A Ramesh
Journal:  J Ethnopharmacol       Date:  2009-11-05       Impact factor: 4.360

7.  Dietary carotenoid lutein protects against DNA damage and alterations of the redox status induced by cisplatin in human derived HepG2 cells.

Authors:  Juliana Mara Serpeloni; Gustavo Rafael Mazzaron Barcelos; José Pedro Friedmann Angeli; Adriana Zerlotti Mercadante; Maria Lourdes Pires Bianchi; Lusânia Maria Greggi Antunes
Journal:  Toxicol In Vitro       Date:  2011-11-26       Impact factor: 3.500

Review 8.  Recognition and processing of cisplatin- and oxaliplatin-DNA adducts.

Authors:  Stephen G Chaney; Sharon L Campbell; Ekaterina Bassett; Yibing Wu
Journal:  Crit Rev Oncol Hematol       Date:  2005-01       Impact factor: 6.312

9.  In vivo cytogenetic studies on rat's bone-marrow cells of structurally related Schiff base complexes.

Authors:  Na'il Saleh; Omar F Khabour; Fatima T Esmadi; Etizaz Al-Kofahi
Journal:  Drug Chem Toxicol       Date:  2010-10-19       Impact factor: 3.356

10.  Mitochondrial dysfunction mediated cisplatin induced toxicity: modulatory role of curcumin.

Authors:  Mohammad Waseem; Suhel Parvez
Journal:  Food Chem Toxicol       Date:  2012-12-12       Impact factor: 6.023
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  4 in total

1.  Assessment of genotoxicity of vincristine, vinblastine and vinorelbine in human cultured lymphocytes: a comparative study.

Authors:  N M Mhaidat; K H Alzoubi; O F Khabour; K Z Alawneh; L A Raffee; E S Alsatari; E I Hussein; K E Bani-Hani
Journal:  Balkan J Med Genet       Date:  2016-08-02       Impact factor: 0.519

2.  Protective Effect of Tempol against Cisplatin-Induced Ototoxicity.

Authors:  Cha Kyung Youn; Jun Kim; Eu-Ri Jo; Jeonghyun Oh; Nam Yong Do; Sung Il Cho
Journal:  Int J Mol Sci       Date:  2016-11-18       Impact factor: 5.923

3.  Vitamin B12 protects against DNA damage induced by hydrochlorothiazide.

Authors:  Karem H Alzoubi; Erva Bayraktar; Omar Khabour; Sayer I Al-Azzam
Journal:  Saudi Pharm J       Date:  2018-04-03       Impact factor: 4.330

4.  Genotoxicity of cisplatin and carboplatin in cultured human lymphocytes: a comparative study.

Authors:  Belal Azab; Anood Alassaf; Abdulrahman Abu-Humdan; Zain Dardas; Hashem Almousa; Mohammad Alsalem; Omar Khabour; Hana Hammad; Tareq Saleh; Abdalla Awidi
Journal:  Interdiscip Toxicol       Date:  2020-02-20
  4 in total

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