Kemal Turker Ulutas1, Recep Dokuyucu2, Fatih Sefil2, Erhan Yengil3, Ahmet Taner Sumbul4, Hatice Rizaoglu5, Ihsan Ustun6, Erkan Yula7, Tevfik Sabuncu8, Cumali Gokce6. 1. Department of Biochemistry, Kadirli State Hospital Osmaniye, Turkey. 2. Department of Medical Physiology, Medical Faculty, Mustafa Kemal University Hatay, Turkey. 3. Department of Family Medicine, Medical Faculty, Mustafa Kemal University Hatay, Turkey. 4. Department of Medical Oncology, Medical Faculty, Mustafa Kemal University Hatay, Turkey. 5. Department of Internal Medicine, Medical Faculty, Mustafa Kemal University Hatay, Turkey. 6. Department of Endocrinology and Metabolism, Mustafa Kemal University Hatay, Turkey. 7. Department of Medical Microbiology, Medical Faculty, Mustafa Kemal University Hatay, Turkey. 8. Department of Endocrinology and Metabolism, Medical Faculty, Harran University Sanliurfa, Turkey.
Abstract
OBJECTIVE: Platelets have an important role in atherosclerosis and arterial thrombosis. Cardiovascular complication prevalence of type 2 diabetes mellitus (type 2 DM) may be associated with glycosylated hemoglobin (HbA1c) and mean platelet volume (MPV). The aim of the study was to investigate if platelets were activated in diabetes and its associated vascular complications by measuring the MPV in the diabetics compared to the non-diabetics, and to determine the correlation of MPV with fasting serum glucose (FSG), HbA1c and duration of diabetes in the diabetic patients, respectively. MATERIALS AND METHODS: The study carried out in 65 patients with type 2 DM and 40 non-diabetic subjects. In addition to non-diabetic patients, all diabetic patients were divided into two groups according to their HbA1c levels: group A consisted of patients with HbA1c levels ≤7% and group B consisted of patients with HbA1c levels >7%. RESULTS: MPV was significantly higher in Group B as compared to both non-diabetics and Group A. MPV had a high positive correlation with HbA1c and FSG, as with diabetes duration. It is found that MPV was increased in type 2 DM. CONCLUSION: Our findings suggested an association between MPV and HbA1c. Therefore, MPV would be a beneficial prognostic marker of cardio-vascular complications in patients with type 2 DM.
OBJECTIVE: Platelets have an important role in atherosclerosis and arterial thrombosis. Cardiovascular complication prevalence of type 2 diabetes mellitus (type 2 DM) may be associated with glycosylated hemoglobin (HbA1c) and mean platelet volume (MPV). The aim of the study was to investigate if platelets were activated in diabetes and its associated vascular complications by measuring the MPV in the diabetics compared to the non-diabetics, and to determine the correlation of MPV with fasting serum glucose (FSG), HbA1c and duration of diabetes in the diabeticpatients, respectively. MATERIALS AND METHODS: The study carried out in 65 patients with type 2 DM and 40 non-diabetic subjects. In addition to non-diabeticpatients, all diabeticpatients were divided into two groups according to their HbA1c levels: group A consisted of patients with HbA1c levels ≤7% and group B consisted of patients with HbA1c levels >7%. RESULTS: MPV was significantly higher in Group B as compared to both non-diabetics and Group A. MPV had a high positive correlation with HbA1c and FSG, as with diabetes duration. It is found that MPV was increased in type 2 DM. CONCLUSION: Our findings suggested an association between MPV and HbA1c. Therefore, MPV would be a beneficial prognostic marker of cardio-vascular complications in patients with type 2 DM.
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