Miika Värri1, Tomi-Pekka Tuomainen2, Risto Honkanen3, Toni Rikkonen4, Leo Niskanen5, Heikki Kröger6, Marjo T Tuppurainen7. 1. Bone and Cartilage Research Unit (BCRU), Surgery, Institute of Clinical Medicine, University of Eastern Finland, Mediteknia Building, P.O. Box 1627, FI-70211 Kuopio, Finland. Electronic address: mvarri@student.uef.fi. 2. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Canthia Building, P.O.Box 1627, FI-70211 Kuopio, Finland. 3. Bone and Cartilage Research Unit (BCRU), Surgery, Institute of Clinical Medicine, University of Eastern Finland, Mediteknia Building, P.O. Box 1627, FI-70211 Kuopio, Finland; Lapland Hospital District, P.O. Box 8041, FI-96101 Rovaniemi, Finland. 4. Bone and Cartilage Research Unit (BCRU), Surgery, Institute of Clinical Medicine, University of Eastern Finland, Mediteknia Building, P.O. Box 1627, FI-70211 Kuopio, Finland. 5. Institute of Clinical Medicine, University of Eastern Finland and Finnish Medicines Agency Fimea, Mannerheimintie 103b, FI-00280 Helsinki, Finland. 6. Bone and Cartilage Research Unit (BCRU), Surgery, Institute of Clinical Medicine, University of Eastern Finland, Mediteknia Building, P.O. Box 1627, FI-70211 Kuopio, Finland; Department of Orthopaedics, Traumatology and Hand Surgery, Kuopio University Hospital, Building 3, P.O. Box 100, FI-70029 Kuopio, Finland. 7. Bone and Cartilage Research Unit (BCRU), Surgery, Institute of Clinical Medicine, University of Eastern Finland, Mediteknia Building, P.O. Box 1627, FI-70211 Kuopio, Finland; Department of Obstetrics and Gynaecology, Kuopio University Hospital, Building 6, P.O. Box 100, FI-70029 Kuopio, Finland.
Abstract
OBJECTIVES: Atherosclerosis (AS) and osteoporosis are common diseases in elderly people and may be metabolically related. The aim of this cross-sectional population-based study was to explore the association between common carotid artery intima-media thickness (cIMT), carotid artery calcification (CAC), and BMD in postmenopausal women. In addition, the association of postmenopausal hormone therapy (HT) and selected diseases with cIMT and carotid calcification was studied. STUDY DESIGN: The 290 women (mean age 73.6 years) included in this Bone Brain Atherosclerosis study (OSTPRE-BBA) were randomly selected from the population-based Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) study cohort, Finland. MAIN OUTCOME MEASURES: For this cross-sectional study, cIMT was measured with B-mode ultrasound; femoral neck and total body BMD were measured with dual-energy X-ray absorptiometry. RESULTS: There were no statistically significant associations between mean cIMT and femoral neck T-score (p>0.05). However, an increased maximum cIMT was significantly associated with low femoral neck T-score. In the osteoporotic group (T-score <-2.5, n=20), the maximum cIMT was 2.51±0.88mm (mean±SD); in the normal BMD group (T-score >-1, n=122), it was 1.93±0.64mm (p=0.001). The odds of having CAC were approximately four-fold higher in the osteoporotic group compared with the group with a normal femoral neck T-score (odds ratio [OR]=4.2, p=0.038). The maximum cIMT was smaller in HT users (1.98±0.56mm, n=190) than in non-users (2.16±0.74mm, n=156, p=0.036). CONCLUSIONS: The results of our population-based study suggest that BMD is related to AS, at least in carotid arteries. They indirectly support the hypothesis of partially shared pathophysiological mechanisms between these two disorders.
OBJECTIVES:Atherosclerosis (AS) and osteoporosis are common diseases in elderly people and may be metabolically related. The aim of this cross-sectional population-based study was to explore the association between common carotid artery intima-media thickness (cIMT), carotid artery calcification (CAC), and BMD in postmenopausal women. In addition, the association of postmenopausal hormone therapy (HT) and selected diseases with cIMT and carotid calcification was studied. STUDY DESIGN: The 290 women (mean age 73.6 years) included in this Bone Brain Atherosclerosis study (OSTPRE-BBA) were randomly selected from the population-based Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) study cohort, Finland. MAIN OUTCOME MEASURES: For this cross-sectional study, cIMT was measured with B-mode ultrasound; femoral neck and total body BMD were measured with dual-energy X-ray absorptiometry. RESULTS: There were no statistically significant associations between mean cIMT and femoral neck T-score (p>0.05). However, an increased maximum cIMT was significantly associated with low femoral neck T-score. In the osteoporotic group (T-score <-2.5, n=20), the maximum cIMT was 2.51±0.88mm (mean±SD); in the normal BMD group (T-score >-1, n=122), it was 1.93±0.64mm (p=0.001). The odds of having CAC were approximately four-fold higher in the osteoporotic group compared with the group with a normal femoral neck T-score (odds ratio [OR]=4.2, p=0.038). The maximum cIMT was smaller in HT users (1.98±0.56mm, n=190) than in non-users (2.16±0.74mm, n=156, p=0.036). CONCLUSIONS: The results of our population-based study suggest that BMD is related to AS, at least in carotid arteries. They indirectly support the hypothesis of partially shared pathophysiological mechanisms between these two disorders.
Authors: Jonathan Q Purnell; Henryk F Urbanski; Paul Kievit; Charles T Roberts; Cynthia L Bethea Journal: Endocrinology Date: 2019-04-01 Impact factor: 4.736
Authors: Miika Värri; Leo Niskanen; Tomi-Pekka Tuomainen; Risto Honkanen; Heikki Kröger; Marjo T Tuppurainen Journal: Vasc Health Risk Manag Date: 2020-12-02
Authors: J Pepe; G Della Grotta; R Santori; V De Martino; M Occhiuto; M Cilli; S Minisola; C Cipriani Journal: J Endocrinol Invest Date: 2021-02-12 Impact factor: 4.256