Maria Carmela Bloise1, Isabella Berardelli1, Valentina Roselli1, Massimo Pasquini1, Paola Stirpe1, Carlo Colosimo1, Alfredo Berardelli2, Giovanni Fabbrini3. 1. Department of Neurology and Psychiatry, Sapienza University of Rome, Italy. 2. Department of Neurology and Psychiatry, Sapienza University of Rome, Italy; IRCSS Neuromed Institute, Pozzilli, IS, Italy. 3. Department of Neurology and Psychiatry, Sapienza University of Rome, Italy; IRCSS Neuromed Institute, Pozzilli, IS, Italy. Electronic address: giovanni.fabbrini@uniroma1.it.
Abstract
OBJECTIVES: To investigate the frequency and the different types of psychiatric disturbances in PSP patients using validated psychiatric instruments. METHODS: We conducted a case-control study using the Structured Clinical Interview (SCID-I) for DSM-IV to investigate psychiatric disorders in 28 PSP patients and 28 age and gender matched healthy controls. PSP severity was scored using the PSP rating scale; cognitive functions were assessed using the Montreal Cognitive Assessment scale and the Frontal Assessment Battery scale. RESULTS: SCID-I disclosed that psychiatric disturbances were more frequent in PSP patients (53%) than in healthy controls (17.8%) (p = 0.005). Psychiatric disorders in PSP patients were characterized by mood disorders. Depression due to PSP was the most frequent diagnosis and was found in 8 of the 15 patients with depressive disorders. None of the PSP patients had a diagnosis of other SCID-I disorders. No clinical or demographic differences were found when comparing PSP patients with and without psychiatric disturbances. CONCLUSIONS: Psychiatric disturbances, namely depressive disorders, were more frequent in PSP patients than in controls. A thorough evaluation of psychiatric disorders is important to insure appropriate treatment of PSP patients..
OBJECTIVES: To investigate the frequency and the different types of psychiatric disturbances in PSPpatients using validated psychiatric instruments. METHODS: We conducted a case-control study using the Structured Clinical Interview (SCID-I) for DSM-IV to investigate psychiatric disorders in 28 PSPpatients and 28 age and gender matched healthy controls. PSP severity was scored using the PSP rating scale; cognitive functions were assessed using the Montreal Cognitive Assessment scale and the Frontal Assessment Battery scale. RESULTS:SCID-I disclosed that psychiatric disturbances were more frequent in PSPpatients (53%) than in healthy controls (17.8%) (p = 0.005). Psychiatric disorders in PSPpatients were characterized by mood disorders. Depression due to PSP was the most frequent diagnosis and was found in 8 of the 15 patients with depressive disorders. None of the PSPpatients had a diagnosis of other SCID-I disorders. No clinical or demographic differences were found when comparing PSPpatients with and without psychiatric disturbances. CONCLUSIONS:Psychiatric disturbances, namely depressive disorders, were more frequent in PSPpatients than in controls. A thorough evaluation of psychiatric disorders is important to insure appropriate treatment of PSPpatients..
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