Literature DB >> 24954010

Crosstalk between DNA repair and cancer stem cell (CSC) associated intracellular pathways.

Sergej Skvortsov1, Paul Debbage2, Peter Lukas3, Ira Skvortsova3.   

Abstract

DNA damaging agents (ionizing radiation and chemotherapeutics) are considered as most effective in cancer treatment. However, there is a subpopulation of carcinoma cells within the tumour demonstrating resistance to DNA damaging treatment approaches. It is suggested that limited tumour response to this kind of therapy can be associated with specific molecular properties of carcinoma stem cells (CSCs) representing the most refractory cell subpopulation. This review article presents novel data about molecular features of CSCs underlying DNA damage response and related intracellular signalling.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Ape1/Ref-1; Cancer stem cells; DNA repair; Intracellular signalling; MRN complex

Mesh：

Substances：

Year:  2014        PMID： 24954010     DOI： 10.1016/j.semcancer.2014.06.002

Source DB:  PubMed          Journal:  Semin Cancer Biol        ISSN： 1044-579X            Impact factor:   15.707


  32 in total

1.  Evidence for embryonic stem-like signature and epithelial-mesenchymal transition features in the spheroid cells derived from lung adenocarcinoma.

Authors:  Raheleh Roudi; Zahra Madjd; Marzieh Ebrahimi; Ali Najafi; Alireza Korourian; Ahmad Shariftabrizi; Ali Samadikuchaksaraei
Journal:  Tumour Biol       Date:  2016-04-05

Review 2.  New Opportunities and Challenges to Defeat Cancer Stem Cells.

Authors:  Erika K Ramos; Andrew D Hoffmann; Stanton L Gerson; Huiping Liu
Journal:  Trends Cancer       Date:  2017-09-21

3.  Bcl-2-like Protein 11 (BIM) Expression Is Associated with Favorable Prognosis for Patients with Cervical Cancer.

Authors:  Bo Wook Kim; Hanbyoul Cho; Kris Ylaya; Haruhisa Kitano; Joon-Yong Chung; Stephen M Hewitt; Jae-Hoon Kim
Journal:  Anticancer Res       Date:  2017-09       Impact factor: 2.480

Review 4.  Potential role of cancer stem cells as biomarkers and therapeutic targets in cervical cancer.

Authors:  Niyati Sudhalkar; Nidul P Rathod; Ashwathi Mathews; Supriya Chopra; Harshini Sriram; Shyam K Shrivastava; Jayant S Goda
Journal:  Cancer Rep (Hoboken)       Date:  2018-11-08

5.  Differential role of Wnt signaling and base excision repair pathways in gastric adenocarcinoma aggressiveness.

Authors:  Alireza Korourian; Raheleh Roudi; Ahmad Shariftabrizi; Elham Kalantari; Kambiz Sotoodeh; Zahra Madjd
Journal:  Clin Exp Med       Date:  2016-12-01       Impact factor: 3.984

Review 6.  Drug resistance mechanisms of cancer stem-like cells and their therapeutic potential as drug targets.

Authors:  Takahiko Murayama; Noriko Gotoh
Journal:  Cancer Drug Resist       Date:  2019-09-19

7.  Graphene oxide selectively targets cancer stem cells, across multiple tumor types: implications for non-toxic cancer treatment, via "differentiation-based nano-therapy".

Authors:  Marco Fiorillo; Andrea F Verre; Maria Iliut; Maria Peiris-Pagés; Bela Ozsvari; Ricardo Gandara; Anna Rita Cappello; Federica Sotgia; Aravind Vijayaraghavan; Michael P Lisanti
Journal:  Oncotarget       Date:  2015-02-28

8.  Doxycycline and therapeutic targeting of the DNA damage response in cancer cells: old drug, new purpose.

Authors:  Maria Peiris-Pagès; Federica Sotgia; Michael P Lisanti
Journal:  Oncoscience       Date:  2015-08-24

9.  Rac1 as a multifunctional therapeutic target to prevent and combat cancer metastasis.

Authors:  Sergej Skvortsov; Ira-Ida Skvortsova; Christoph R Arnold; Alshaimaa Abdelmoez; Gudrun Thurner; Paul Debbage; Peter Lukas
Journal:  Oncoscience       Date:  2014-08-21

10.  MUC1-Mediated Metabolic Alterations Regulate Response to Radiotherapy in Pancreatic Cancer.

Authors:  Venugopal Gunda; Joshua Souchek; Jaime Abrego; Surendra K Shukla; Gennifer D Goode; Enza Vernucci; Aneesha Dasgupta; Nina V Chaika; Ryan J King; Sicong Li; Shuo Wang; Fang Yu; Tadayoshi Bessho; Chi Lin; Pankaj K Singh
Journal:  Clin Cancer Res       Date:  2017-07-18       Impact factor: 13.801
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