Literature DB >> 24953014

Brain metastasis: new opportunities to tackle therapeutic resistance.

Joan Seoane1, Leticia De Mattos-Arruda2.   

Abstract

Brain metastasis is a devastating complication of cancer with unmet therapeutic needs. The incidence of brain metastasis has been rising in cancer patients and its response to treatment is limited due to the singular characteristics of brain metastasis (i.e., blood-brain-barrier, immune system, stroma). Despite improvements in the treatment and control of extracranial disease, the outcomes of patients with brain metastasis remain dismal. The mechanisms that allow tumor cells to promulgate metastases to the brain remain poorly understood. Further work is required to identify the molecular alterations inherent to brain metastasis in order to identify novel therapeutic targets and explicate the mechanisms of resistance to systemic therapeutics. In this article, we review current knowledge of the unique characteristics of brain metastasis, implications in therapeutic resistance, and the possibility of developing biomarkers to rationally guide the use of targeted agents.
Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Brain metastasis; Targeted therapy; Therapeutic resistance

Mesh：

Substances：

Year:  2014        PMID： 24953014      PMCID： PMC5528619          DOI： 10.1016/j.molonc.2014.05.009

Source DB:  PubMed          Journal:  Mol Oncol        ISSN： 1574-7891            Impact factor:   6.603


  124 in total

1.  Differential induction of interleukin-1beta and tumour necrosis factor-alpha may account for specific patterns of leukocyte recruitment in the brain.

Authors:  Donatienne Blond; Sandra J Campbell; Angus G Butchart; V Hugh Perry; Daniel C Anthony
Journal:  Brain Res       Date:  2002-12-20       Impact factor: 3.252

2.  Complete regression of a previously untreated melanoma brain metastasis with ipilimumab.

Authors:  Noël E C Schartz; Cécile Farges; Isabelle Madelaine; Heriberto Bruzzoni; Fabien Calvo; Axel Hoos; Céleste Lebbé
Journal:  Melanoma Res       Date:  2010-06       Impact factor: 3.599

3.  The role of immune cells in brain metastasis of lung cancer cells and neuron-tumor cell interaction.

Authors:  M Noda; T Seike; K Fujita; Y Yamakawa; M Kido; H Iguchi
Journal:  Ross Fiziol Zh Im I M Sechenova       Date:  2009-12

4.  miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4.

Authors:  Hiroshi Okuda; Fei Xing; Puspa R Pandey; Sambad Sharma; Misako Watabe; Sudha K Pai; Yin-Yuan Mo; Megumi Iiizumi-Gairani; Shigeru Hirota; Yin Liu; Kerui Wu; Radhika Pochampally; Kounosuke Watabe
Journal:  Cancer Res       Date:  2013-02-05       Impact factor: 12.701

5.  Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer.

Authors:  James W Welsh; Ritsuko Komaki; Arya Amini; Mark F Munsell; Wyatt Unger; Pamela K Allen; Joe Y Chang; Jeffrey S Wefel; Susan L McGovern; Linda L Garland; Su S Chen; Jamie Holt; Zhongxing Liao; Paul Brown; Erik Sulman; John V Heymach; Edward S Kim; Baldassarre Stea
Journal:  J Clin Oncol       Date:  2013-01-22       Impact factor: 44.544

6.  Glioblastoma survival in the United States improved after Food and Drug Administration approval of bevacizumab: a population-based analysis.

Authors:  Derek R Johnson; Heather E Leeper; Joon H Uhm
Journal:  Cancer       Date:  2013-07-18       Impact factor: 6.860

7.  Activation of notch signaling in a xenograft model of brain metastasis.

Authors:  Do-Hyun Nam; Hye-Min Jeon; Shiyeon Kim; Mi Hyun Kim; Young-Ju Lee; Min Su Lee; Hyunggee Kim; Kyeung Min Joo; Dong-Sup Lee; Janet E Price; Sa Ik Bang; Woong-Yang Park
Journal:  Clin Cancer Res       Date:  2008-07-01       Impact factor: 12.531

8.  Downregulation of miR-145 contributes to lung adenocarcinoma cell growth to form brain metastases.

Authors:  Chunyang Zhao; Yan Xu; Yongqiang Zhang; Weiwei Tan; Jianxin Xue; Zongze Yang; You Zhang; You Lu; Xun Hu
Journal:  Oncol Rep       Date:  2013-09-10       Impact factor: 3.906

9.  Epidemiology and prognosis of brain metastases.

Authors:  Keith J Stelzer
Journal:  Surg Neurol Int       Date:  2013-05-02

10.  Bevacizumab in the treatment of five patients with breast cancer and brain metastases: Japan Breast Cancer Research Network-07 trial.

Authors:  Daigo Yamamoto; Satoru Iwase; Yu Tsubota; Noriko Sueoka; Chizuko Yamamoto; Kaoru Kitamura; Hiroki Odagiri; Yoshinori Nagumo
Journal:  Onco Targets Ther       Date:  2012-09-17       Impact factor: 4.147
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  15 in total

Review 1.  Brain metastasis: new opportunities to tackle therapeutic resistance.

Authors:  Joan Seoane; Leticia De Mattos-Arruda
Journal:  Mol Oncol       Date:  2014-06-02       Impact factor: 6.603

2.  Proteotranscriptomic Profiling of 231-BR Breast Cancer Cells: Identification of Potential Biomarkers and Therapeutic Targets for Brain Metastasis.

Authors:  Matthew D Dun; Robert J Chalkley; Sam Faulkner; Sheridan Keene; Kelly A Avery-Kiejda; Rodney J Scott; Lasse G Falkenby; Murray J Cairns; Martin R Larsen; Ralph A Bradshaw; Hubert Hondermarck
Journal:  Mol Cell Proteomics       Date:  2015-06-03       Impact factor: 5.911

3.  Cancer drug resistance: old concept, novel solutions required.

Authors:  Daniel S Peeper
Journal:  Mol Oncol       Date:  2014-08-07       Impact factor: 6.603

4.  Novel flow cytometric analysis of the blood-brain barrier.

Authors:  Dionna W Williams; Lydia Tesfa; Joan W Berman
Journal:  Cytometry A       Date:  2015-04-30       Impact factor: 4.355

5.  Quality of life and efficacy of temozolomide combined with whole-brain radiotherapy in patients with brain metastases from non-small-cell lung cancer.

Authors:  Yajuan Lv; Jiandong Zhang; Zhen Liu; Ning Liang; Yuan Tian
Journal:  Mol Clin Oncol       Date:  2018-05-10

6.  Near-infrared fluorescence heptamethine carbocyanine dyes mediate imaging and targeted drug delivery for human brain tumor.

Authors:  Jason Boyang Wu; Changhong Shi; Gina Chia-Yi Chu; Qijin Xu; Yi Zhang; Qinlong Li; John S Yu; Haiyen E Zhau; Leland W K Chung
Journal:  Biomaterials       Date:  2015-07-16       Impact factor: 12.479

Review 7.  ctDNA-Based Liquid Biopsy of Cerebrospinal Fluid in Brain Cancer.

Authors:  Laura Escudero; Francisco Martínez-Ricarte; Joan Seoane
Journal:  Cancers (Basel)       Date:  2021-04-21       Impact factor: 6.639

8.  Whole brain radiotherapy plus concurrent chemotherapy in non-small cell lung cancer patients with brain metastases: a meta-analysis.

Authors:  Hong Qin; Feng Pan; Jianjun Li; Xiaoli Zhang; Houjie Liang; Zhihua Ruan
Journal:  PLoS One       Date:  2014-10-27       Impact factor: 3.240

9.  Palliative whole-brain radiotherapy and health- related quality of life for patients with brain metastasis in cancer.

Authors:  Ying Gao; Fei Gao; Jin-Lu Ma; Dong-Li Zhao
Journal:  Neuropsychiatr Dis Treat       Date:  2015-08-21       Impact factor: 2.570

10.  Dietary Selenium Supplementation Modulates Growth of Brain Metastatic Tumors and Changes the Expression of Adhesion Molecules in Brain Microvessels.

Authors:  Jagoda K Wrobel; Gretchen Wolff; Rijin Xiao; Ronan F Power; Michal Toborek
Journal:  Biol Trace Elem Res       Date:  2015-12-26       Impact factor: 3.738
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