Inhibition of plasma coagulation and platelet aggregation with structural analogs of taurine chloramine.

We studied the effects of amide and N-alkyl analogs of taurine chloramine on rabbit plasma coagulation and platelet aggregation. Alkyl analog N-isopropyl-N-chlorotaurine produced greater increase in plasma coagulation time after its activation by the contact method or with thrombin than amide analog N-propionyl-N-chlorotaurine. In case of coagulation induced by the tissue factor, the test analogs produced similar effect. Inhibition of platelet aggregation in platelet-rich plasma under the effect of N-isopropyl-N-chlorotaurine depended on the nature of the agonist. Aggregation was suppressed stronger under conditions of collagen stimulation than in response to ADP agonist. Estimated partial charges of the chlorine atom in amide analogs were 5-fold higher than in N-alkyl analogs. This fact determined the difference in the chemoselective interaction with sulfur-containing amino acid residues in targets and the specific features of anticoagulation and antiaggregant effects of two analogs of taurine chloramine.