Katherine E Poruk1, Jian Ying2, Jeremy R Chidester3, Joshua R Olson4, Cindy B Matsen5, Leigh Neumayer5, Jayant Agarwal6. 1. Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA. 2. Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA. 3. Department of Plastic and Reconstructive Surgery, Loma Linda University Medical Center, Loma Linda, CA, USA. 4. Division of Plastic and Reconstructive Surgery, University of Utah School of Medicine, 30 North 1900 East 3B 400, Salt Lake City, UT 84132, USA. 5. Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA. 6. Division of Plastic and Reconstructive Surgery, University of Utah School of Medicine, 30 North 1900 East 3B 400, Salt Lake City, UT 84132, USA. Electronic address: Jay.Agarwal@hsc.utah.edu.
Abstract
BACKGROUND: Nipple-sparing mastectomy (NSM) has been increasingly used to treat women with breast cancer who wish to preserve the overlying breast skin, but concern remains regarding tumor recurrence. We report our experience performing NSM for breast cancer treatment and prophylaxis over a 6-year period. METHODS: A retrospective chart review on patients undergoing NSM or skin-sparing mastectomy (SSM) from 2005 to 2011 was performed. RESULTS: NSM patients were younger (P < .001), had a lower body mass index (P < .001), and were associated with a family cancer risk (P = .01) but not genetic risk (P = .83). There was no difference in the distance between the tumor and the nipple-areola complex when comparing NSM and SSM (P = .47). There was no significant difference in recurrence (P = .08) or survival (P = .38) when comparing NSM and SSM after controlling for age, stage, and surgery laterality. CONCLUSIONS: There was no difference in survival or cancer recurrence for NSM or SSM. NSM does not increase the risk of recurrence or decrease survival.
BACKGROUND: Nipple-sparing mastectomy (NSM) has been increasingly used to treat women with breast cancer who wish to preserve the overlying breast skin, but concern remains regarding tumor recurrence. We report our experience performing NSM for breast cancer treatment and prophylaxis over a 6-year period. METHODS: A retrospective chart review on patients undergoing NSM or skin-sparing mastectomy (SSM) from 2005 to 2011 was performed. RESULTS: NSM patients were younger (P < .001), had a lower body mass index (P < .001), and were associated with a family cancer risk (P = .01) but not genetic risk (P = .83). There was no difference in the distance between the tumor and the nipple-areola complex when comparing NSM and SSM (P = .47). There was no significant difference in recurrence (P = .08) or survival (P = .38) when comparing NSM and SSM after controlling for age, stage, and surgery laterality. CONCLUSIONS: There was no difference in survival or cancer recurrence for NSM or SSM. NSM does not increase the risk of recurrence or decrease survival.
Authors: Jai Min Ryu; Seok Jin Nam; Seok Won Kim; Se Kyung Lee; Soo Youn Bae; Ha Woo Yi; Sungmin Park; Hyun-June Paik; Jeong Eon Lee Journal: World J Surg Date: 2016-08 Impact factor: 3.352
Authors: Zoran Radovanovic; Milan Ranisavljevic; Dragana Radovanovic; Ferenc Vicko; Tatjana Ivkovic-Kapicl; Nenad Solajic Journal: Breast Care (Basel) Date: 2018-06-20 Impact factor: 2.860
Authors: Bruna S Mota; Rachel Riera; Marcos Desidério Ricci; Jessica Barrett; Tiago B de Castria; Álvaro N Atallah; Jose Luiz B Bevilacqua Journal: Cochrane Database Syst Rev Date: 2016-11-29