Literature DB >> 24944315

Prostate cancer SubtyPINg biomarKers and outcome: is clarity emERGing?

Steven C Smith1, Scott A Tomlins2.   

Abstract

Molecular prostate cancer subtypes have been proposed on the basis of mutually exclusive SPINK1 and ERG overexpression, with conflicting reports on their prognostic ability. Flavin and colleagues report that SPINK1 is neither prognostic nor absolutely mutually exclusive with ERG, raising important questions about prostate cancer molecular subtyping and prognostic biomarker evaluation. ©2014 American Association for Cancer Research.

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Year:  2014        PMID： 24944315      PMCID： PMC4167216          DOI： 10.1158/1078-0432.CCR-14-0818

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  11 in total

1.  SPINK1 protein expression and prostate cancer progression.

Authors:  Richard Flavin; Andreas Pettersson; Whitney K Hendrickson; Michelangelo Fiorentino; Stephen Finn; Lauren Kunz; Gregory L Judson; Rosina Lis; Dyane Bailey; Christopher Fiore; Elizabeth Nuttall; Neil E Martin; Edward Stack; Kathryn L Penney; Jennifer R Rider; Jennifer Sinnott; Christopher Sweeney; Howard D Sesso; Katja Fall; Edward Giovannucci; Philip Kantoff; Meir Stampfer; Massimo Loda; Lorelei A Mucci
Journal:  Clin Cancer Res       Date:  2014-03-31       Impact factor: 12.531

2.  Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.

Authors:  Christopher E Barbieri; Sylvan C Baca; Michael S Lawrence; Francesca Demichelis; Mirjam Blattner; Jean-Philippe Theurillat; Thomas A White; Petar Stojanov; Eliezer Van Allen; Nicolas Stransky; Elizabeth Nickerson; Sung-Suk Chae; Gunther Boysen; Daniel Auclair; Robert C Onofrio; Kyung Park; Naoki Kitabayashi; Theresa Y MacDonald; Karen Sheikh; Terry Vuong; Candace Guiducci; Kristian Cibulskis; Andrey Sivachenko; Scott L Carter; Gordon Saksena; Douglas Voet; Wasay M Hussain; Alex H Ramos; Wendy Winckler; Michelle C Redman; Kristin Ardlie; Ashutosh K Tewari; Juan Miguel Mosquera; Niels Rupp; Peter J Wild; Holger Moch; Colm Morrissey; Peter S Nelson; Philip W Kantoff; Stacey B Gabriel; Todd R Golub; Matthew Meyerson; Eric S Lander; Gad Getz; Mark A Rubin; Levi A Garraway
Journal:  Nat Genet       Date:  2012-05-20       Impact factor: 38.330

3.  Marked heterogeneity of ERG expression in large primary prostate cancers.

Authors:  Sarah Minner; Michael Gärtner; Fabian Freudenthaler; Melanie Bauer; Martina Kluth; Georg Salomon; Hans Heinzer; Markus Graefen; Carsten Bokemeyer; Ronald Simon; Guido Sauter; Thorsten Schlomm; Waldemar Wilczak
Journal:  Mod Pathol       Date:  2012-08-17       Impact factor: 7.842

4.  Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer.

Authors:  Sameer Jhavar; Daniel Brewer; Sandra Edwards; Zsofia Kote-Jarai; Gerhardt Attard; Jeremy Clark; Penny Flohr; Timothy Christmas; Alan Thompson; Matthew Parker; Christopher Shepherd; Ulf-Hakan Stenman; Tania Marchbank; Raymond J Playford; Christopher Woodhouse; Christopher Ogden; Cyril Fisher; Gyula Kovacs; Cathy Corbishley; Charles Jameson; Andy Norman; Johann De-Bono; Anders Bjartell; Rosalind Eeles; Colin S Cooper
Journal:  BJU Int       Date:  2008-11-25       Impact factor: 5.588

5.  Novel RNA hybridization method for the in situ detection of ETV1, ETV4, and ETV5 gene fusions in prostate cancer.

Authors:  Lakshmi P Kunju; Shannon Carskadon; Javed Siddiqui; Scott A Tomlins; Arul M Chinnaiyan; Nallasivam Palanisamy
Journal:  Appl Immunohistochem Mol Morphol       Date:  2014-09

6.  SPINK1 expression is tightly linked to 6q15- and 5q21-deleted ERG-fusion negative prostate cancers but unrelated to PSA recurrence.

Authors:  Katharina Grupp; Franz Diebel; Hüseyin Sirma; Ronald Simon; Karin Breitmeyer; Stefan Steurer; Claudia Hube-Magg; Kristina Prien; Taher Pham; Philipp Weigand; Uwe Michl; Hans Heinzer; Martina Kluth; Sarah Minner; Maria Christina Tsourlakis; Jakob R Izbicki; Guido Sauter; Thorsten Schlomm; Waldemar Wilczak
Journal:  Prostate       Date:  2013-07-10       Impact factor: 4.104

7.  The role of SPINK1 in ETS rearrangement-negative prostate cancers.

Authors:  Scott A Tomlins; Daniel R Rhodes; Jianjun Yu; Sooryanarayana Varambally; Rohit Mehra; Sven Perner; Francesca Demichelis; Beth E Helgeson; Bharathi Laxman; David S Morris; Qi Cao; Xuhong Cao; Ove Andrén; Katja Fall; Laura Johnson; John T Wei; Rajal B Shah; Hikmat Al-Ahmadie; James A Eastham; Scott E Eggener; Samson W Fine; Kristina Hotakainen; Ulf-Håkan Stenman; Alex Tsodikov; William L Gerald; Hans Lilja; Victor E Reuter; Phillip W Kantoff; Peter T Scardino; Mark A Rubin; Anders S Bjartell; Arul M Chinnaiyan
Journal:  Cancer Cell       Date:  2008-06       Impact factor: 31.743

8.  ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratification.

Authors:  B Furusato; S-H Tan; D Young; A Dobi; C Sun; A A Mohamed; R Thangapazham; Y Chen; G McMaster; T Sreenath; G Petrovics; D G McLeod; S Srivastava; I A Sesterhenn
Journal:  Prostate Cancer Prostatic Dis       Date:  2010-06-29       Impact factor: 5.554

9.  HOXB13 G84E-related familial prostate cancers: a clinical, histologic, and molecular survey.

Authors:  Steven C Smith; Nallasivam Palanisamy; Kimberly A Zuhlke; Anna M Johnson; Javed Siddiqui; Arul M Chinnaiyan; Lakshmi P Kunju; Kathleen A Cooney; Scott A Tomlins
Journal:  Am J Surg Pathol       Date:  2014-05       Impact factor: 6.394

10.  Novel dual-color immunohistochemical methods for detecting ERG-PTEN and ERG-SPINK1 status in prostate carcinoma.

Authors:  Ritu Bhalla; Lakshmi P Kunju; Scott A Tomlins; Kelly Christopherson; Connie Cortez; Shannon Carskadon; Javed Siddiqui; Kyung Park; Juan Miguel Mosquera; Gary A Pestano; Mark A Rubin; Arul M Chinnaiyan; Nallasivam Palanisamy
Journal:  Mod Pathol       Date:  2013-01-25       Impact factor: 7.842
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  8 in total

1.  SPINK1 Overexpression in Localized Prostate Cancer: a Rare Event Inversely Associated with ERG Expression and Exclusive of Homozygous PTEN Deletion.

Authors:  Kuo-Cheng Huang; Andrew Evans; Bryan Donnelly; Tarek A Bismar
Journal:  Pathol Oncol Res       Date:  2016-10-13       Impact factor: 3.201

2.  Characterization of 1577 primary prostate cancers reveals novel biological and clinicopathologic insights into molecular subtypes.

Authors:  Scott A Tomlins; Mohammed Alshalalfa; Elai Davicioni; Nicholas Erho; Kasra Yousefi; Shuang Zhao; Zaid Haddad; Robert B Den; Adam P Dicker; Bruce J Trock; Angelo M DeMarzo; Ashley E Ross; Edward M Schaeffer; Eric A Klein; Cristina Magi-Galluzzi; R Jeffrey Karnes; Robert B Jenkins; Felix Y Feng
Journal:  Eur Urol       Date:  2015-05-08       Impact factor: 20.096

3.  Significantly higher expression levels of androgen receptor are associated with erythroblastosis virus E26 oncogene related gene positive prostate cancer.

Authors:  Jason Rosenbaum; Sally Drew; Wei Huang
Journal:  Am J Clin Exp Urol       Date:  2014-10-02

4.  The association between SPINK1 and clinical outcomes in patients with prostate cancer: a systematic review and meta-analysis.

Authors:  Xingming Zhang; Xiaoxue Yin; Pengfei Shen; Guangxi Sun; Yaojing Yang; Jiandong Liu; Ni Chen; Hao Zeng
Journal:  Onco Targets Ther       Date:  2017-06-22       Impact factor: 4.147

5.  Gene expression analysis of human prostate cell lines with and without tumor metastasis suppressor CD82.

Authors:  Pushpaja Dodla; Vanitha Bhoopalan; Sok Kean Khoo; Cindy Miranti; Suganthi Sridhar
Journal:  BMC Cancer       Date:  2020-12-09       Impact factor: 4.430

Review 6.  Cancer Plasticity: The Role of mRNA Translation.

Authors:  Laura J Lee; David Papadopoli; Michael Jewer; Sonia Del Rincon; Ivan Topisirovic; Mitchell G Lawrence; Lynne-Marie Postovit
Journal:  Trends Cancer       Date:  2020-10-13

7.  Transition zone prostate cancer is associated with better clinical outcomes than peripheral zone cancer.

Authors:  Shun Sato; Takahiro Kimura; Hajime Onuma; Shin Egawa; Hiroyuki Takahashi
Journal:  BJUI Compass       Date:  2020-10-06

8.  Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer.

Authors:  Ritika Tiwari; Nishat Manzar; Vipul Bhatia; Anjali Yadav; Mushtaq A Nengroo; Dipak Datta; Shannon Carskadon; Nilesh Gupta; Michael Sigouros; Francesca Khani; Matti Poutanen; Amina Zoubeidi; Himisha Beltran; Nallasivam Palanisamy; Bushra Ateeq
Journal:  Nat Commun       Date:  2020-01-20       Impact factor: 14.919
  8 in total

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