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Literature DB >> 24944166

Intrinsically germanium-69-labeled iron oxide nanoparticles: synthesis and in-vivo dual-modality PET/MR imaging.

Rubel Chakravarty¹, Hector F Valdovinos, Feng Chen, Christina M Lewis, Paul A Ellison, Haiming Luo, M Elizabeth Meyerand, Robert J Nickles, Weibo Cai.

Abstract

Intrinsically germanium-69-labeled super-paramagnetic iron oxide nanoparticles are synthesized via a newly developed, fast and highly specific chelator-free approach. The biodistribution pattern and the feasibility of (69) Ge-SPION@PEG for in vivo dual-modality positron emission tomography/magnetic resonance (PET/MR) imaging and lymph-node mapping are investigated, which represents the first example of the successful utilization of a (69) Ge-based agent for PET/MR imaging.

Entities: Chemical Disease Species

Keywords: chelator-free radiolabeling; germanium-69; iron oxide nanoparticles; multimodality imaging; positron emission tomography/magnetic resonance (PET/MR) imaging

Mesh：

Substances：

Year: 2014 PMID： 24944166 PMCID： PMC4127144 DOI： 10.1002/adma.201401372

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

17 in total

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