Literature DB >> 24942208

Fibroblast growth factor 20 (FGF20) gene polymorphism and risk of Parkinson's disease: a meta-analysis.

Ruixia Zhu1, Ying Zhu, Xu Liu, Zhiyi He.   

Abstract

Fibroblast growth factor 20 (FGF20) widely expressed in the substantia nigra is a neurotrophic factor and enhances the survival of midbrain dopaminergic neurons. Genetic association between variants in FGF20 gene (rs1721100) and PD has been reported, however, the results have been conflicting. A total of 3,463 PD patients and 4,606 controls from 5 case-control studies, which were identified by searching Web of Science, Embase and PubMed database up to March 2014, were collected for this meta-analysis. The meta-analysis showed an association between FGF20 gene rs1721100 polymorphism and risk of Parkinson's disease under a recessive model (GG versus CG+GG; OR = 1.15, 95 % CI 1.02-1.29, p = 0.02) but not under a dominant model (CG+GG versus CC; OR = 1.03, 95 % CI 0.93-1.13, p = 0.57). These findings suggest that rs1721100 GG genotype within FGF20 gene is a risk factor for PD. To our knowledge, this is the first meta-analysis to access to the association of FGF20 gene rs1721100 polymorphism with PD risk.

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Year:  2014        PMID： 24942208     DOI： 10.1007/s10072-014-1853-y

Source DB:  PubMed          Journal:  Neurol Sci        ISSN： 1590-1874            Impact factor:   3.307


  18 in total

1.  FGF20 rs12720208 SNP and microRNA-433 variation: no association with Parkinson's disease in Spanish patients.

Authors:  Lorena de Mena; Lucía F Cardo; Eliecer Coto; Ana Miar; Marta Díaz; Ana I Corao; Belén Alonso; René Ribacoba; Carlos Salvador; Manuel Menéndez; Germán Morís; Victoria Alvarez
Journal:  Neurosci Lett       Date:  2010-05-13       Impact factor: 3.046

2.  Complete genomic screen in Parkinson disease: evidence for multiple genes.

Authors:  W K Scott; M A Nance; R L Watts; J P Hubble; W C Koller; K Lyons; R Pahwa; M B Stern; A Colcher; B C Hiner; J Jankovic; W G Ondo; F H Allen; C G Goetz; G W Small; D Masterman; F Mastaglia; N G Laing; J M Stajich; B Slotterbeck; M W Booze; R C Ribble; E Rampersaud; S G West; R A Gibson; L T Middleton; A D Roses; J L Haines; B L Scott; J M Vance; M A Pericak-Vance
Journal:  JAMA       Date:  2001-11-14       Impact factor: 56.272

3.  Preferential neurotrophic activity of fibroblast growth factor-20 for dopaminergic neurons through fibroblast growth factor receptor-1c.

Authors:  Shigeki Ohmachi; Tadahisa Mikami; Morichika Konishi; Ayumi Miyake; Nobuyuki Itoh
Journal:  J Neurosci Res       Date:  2003-05-15       Impact factor: 4.164

4.  Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22.

Authors:  H Kirikoshi; N Sagara; T Saitoh; K Tanaka; H Sekihara; K Shiokawa; M Katoh
Journal:  Biochem Biophys Res Commun       Date:  2000-08-02       Impact factor: 3.575

5.  FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain.

Authors:  S Ohmachi; Y Watanabe; T Mikami; N Kusu; T Ibi; A Akaike; N Itoh
Journal:  Biochem Biophys Res Commun       Date:  2000-10-22       Impact factor: 3.575

6.  Gene-gene interaction between FGF20 and MAOB in Parkinson disease.

Authors:  X Gao; W K Scott; G Wang; G Mayhew; Y J Li; J M Vance; E R Martin
Journal:  Ann Hum Genet       Date:  2008-01-20       Impact factor: 1.670

7.  FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression.

Authors:  Christian Wider; Justus C Dachsel; Alexandra I Soto; Michael G Heckman; Nancy N Diehl; Mei Yue; Sarah Lincoln; Jan O Aasly; Kristoffer Haugarvoll; John Q Trojanowski; Spiridon Papapetropoulos; Deborah Mash; Alex Rajput; Ali H Rajput; J Mark Gibson; Timothy Lynch; Dennis W Dickson; Ryan J Uitti; Zbigniew K Wszolek; Matthew J Farrer; Owen A Ross
Journal:  Mov Disord       Date:  2009-02-15       Impact factor: 10.338

8.  [Analysis of the rs12720208 single-nucleotide polymorphism of the FGF20 gene in Russian patients with sporadic Parkinson's disease].

Authors:  V V Ustinova; M I Shadrina; E Iu Fedotova; S N Illarioshkin; S A Limborskaia; P A Slominskiĭ
Journal:  Genetika       Date:  2012-12

9.  Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein.

Authors:  Gaofeng Wang; Joelle M van der Walt; Gregory Mayhew; Yi-Ju Li; Stephan Züchner; William K Scott; Eden R Martin; Jeffery M Vance
Journal:  Am J Hum Genet       Date:  2008-01-31       Impact factor: 11.025

10.  Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients.

Authors:  Jordi Clarimon; Georgia Xiromerisiou; Johanna Eerola; Vanesa Gourbali; Olli Hellström; Euthimios Dardiotis; Terhi Peuralinna; Alexandros Papadimitriou; George M Hadjigeorgiou; Pentti J Tienari; Andrew B Singleton
Journal:  BMC Neurol       Date:  2005-06-20       Impact factor: 2.474
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  4 in total

1.  Genetic analysis of FGF20 in Chinese patients with Parkinson's disease.

Authors:  Xiao-Yi Sun; Ling Wang; Lan Cheng; Nan-Nan Li; Zhong-Jiao Lu; Jun-Ying Li; Rong Peng
Journal:  Neurol Sci       Date:  2017-02-25       Impact factor: 3.307

Review 2.  Theoretical Approaches to Lentiviral Mediated Neurotrophin Delivery in Potential Treatments of Parkinson's Disease.

Authors:  Anam Qudrat; Netra Unni
Journal:  Yale J Biol Med       Date:  2016-06-27

3.  Systematic analysis of genetic variants in Han Chinese patients with sporadic Parkinson's disease.

Authors:  Lamei Yuan; Zhi Song; Xiong Deng; Wen Zheng; Yi Guo; Zhijian Yang; Hao Deng
Journal:  Sci Rep       Date:  2016-09-22       Impact factor: 4.379

4.  Depressive symptoms are associated with a functional polymorphism in a miR-433 binding site in the FGF20 gene.

Authors:  Karen M Jiménez; Angela J Pereira-Morales; Ana Adan; Sandra Lopez-Leon; Diego A Forero
Journal:  Mol Brain       Date:  2018-09-21       Impact factor: 4.041
  4 in total

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