William Ericson-Neilsen1, Alan David Kaye2. 1. Department of Anesthesiology, Ochsner Clinic Foundation, New Orleans, LA. 2. Departments of Anesthesiology and Pharmacology, Louisiana State University Health Sciences Center, New Orleans, LA.
Abstract
BACKGROUND: Since their identification nearly 80 years ago, steroids have played a prominent role in the treatment of many disease states. Many of the clinical roles of steroids are related to their potent antiinflammatory and immune-modulating properties. METHODS: This review summarizes the basic pharmacology, complications, and practice delivery issues regarding steroids. RESULTS: Clinically relevant side effects of steroids are common and problematic. Side effects can occur at a wide range of doses and vary depending on the route of administration. The full spectrum of side effects can be present even in patients taking low doses. CONCLUSIONS: Practitioners must be aware that these drugs might exacerbate a preexisting condition or present a new medical condition. Knowledge of the clinical implications of prescribing these agents is critical.
BACKGROUND: Since their identification nearly 80 years ago, steroids have played a prominent role in the treatment of many disease states. Many of the clinical roles of steroids are related to their potent antiinflammatory and immune-modulating properties. METHODS: This review summarizes the basic pharmacology, complications, and practice delivery issues regarding steroids. RESULTS: Clinically relevant side effects of steroids are common and problematic. Side effects can occur at a wide range of doses and vary depending on the route of administration. The full spectrum of side effects can be present even in patients taking low doses. CONCLUSIONS: Practitioners must be aware that these drugs might exacerbate a preexisting condition or present a new medical condition. Knowledge of the clinical implications of prescribing these agents is critical.
Entities:
Keywords:
Adrenal cortex hormones; diabetes mellitus; drug-related side effects and adverse reactions; glucocorticoids; medication therapy management; mineralocorticoids
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