Cyril Voyant1, Daniel Julian2, Rudy Roustit3, Katia Biffi4, Céline Lantieri4. 1. University of Corsica, CNRS UMR SPE 6134, Campus Grimaldi, 20250 Corte, France ; Hospital of Castelluccio, Radiotherapy Unit, BP 85, 20177 Ajaccio, France. 2. Joseph Fourier University, 38000 Grenoble, France. 3. Centre de la république, Radiotherapy Unit, 63000 Clermont-Ferrand, France. 4. Hospital of Castelluccio, Radiotherapy Unit, BP 85, 20177 Ajaccio, France.
Abstract
BACKGROUND: The limits of TDF (time, dose, and fractionation) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding delivered doses or any future prescriptions relating to treatment changes. AIM: We, therefore, propose a calculation interface under the GNU license to be used for equivalent doses, biological doses, and normal tumor complication probability (Lyman model). MATERIALS AND METHODS: THE METHODOLOGY USED DRAWS FROM SEVERAL SOURCES: the linear-quadratic-linear model of Astrahan, the repopulation effects of Dale, and the prediction of multi-fractionated treatments of Thames. RESULTS AND CONCLUSIONS: The results are obtained from an algorithm that minimizes an ad-hoc cost function, and then compared to an equivalent dose computed using standard calculators in seven French radiotherapy centers.
BACKGROUND: The limits of TDF (time, dose, and fractionation) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding delivered doses or any future prescriptions relating to treatment changes. AIM: We, therefore, propose a calculation interface under the GNU license to be used for equivalent doses, biological doses, and normal tumor complication probability (Lyman model). MATERIALS AND METHODS: THE METHODOLOGY USED DRAWS FROM SEVERAL SOURCES: the linear-quadratic-linear model of Astrahan, the repopulation effects of Dale, and the prediction of multi-fractionated treatments of Thames. RESULTS AND CONCLUSIONS: The results are obtained from an algorithm that minimizes an ad-hoc cost function, and then compared to an equivalent dose computed using standard calculators in seven French radiotherapy centers.
Entities:
Keywords:
Fractionation; Linear quadratic; Radiobiology; Repopulation; Time effect
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