Literature DB >> 24936241

Pharmaceutical profiling case study in disruption.

Edward H Kerns1.   

Abstract

Year:  2013        PMID： 24936241      PMCID： PMC4056923          DOI： 10.1021/ml300448g

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


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  8 in total

Review 1.  Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.

Authors:  C A Lipinski; F Lombardo; B W Dominy; P J Feeney
Journal:  Adv Drug Deliv Rev       Date:  2001-03-01       Impact factor: 15.470

2.  Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

Authors:  R S Obach
Journal:  Drug Metab Dispos       Date:  1999-11       Impact factor: 3.922

Review 3.  Property-based design: optimization of drug absorption and pharmacokinetics.

Authors:  H van De Waterbeemd; D A Smith; K Beaumont; D K Walker
Journal:  J Med Chem       Date:  2001-04-26       Impact factor: 7.446

4.  A novel relay method for determining low-clearance values.

Authors:  Li Di; Patrick Trapa; R Scott Obach; Karen Atkinson; Yi-An Bi; Angela C Wolford; Beijing Tan; Thomas S McDonald; Yurong Lai; Larry M Tremaine
Journal:  Drug Metab Dispos       Date:  2012-05-29       Impact factor: 3.922

Review 5.  The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery.

Authors:  Dennis A Smith; Li Di; Edward H Kerns
Journal:  Nat Rev Drug Discov       Date:  2010-12       Impact factor: 84.694

6.  Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties.

Authors:  Travis T Wager; Xinjun Hou; Patrick R Verhoest; Anabella Villalobos
Journal:  ACS Chem Neurosci       Date:  2010-03-25       Impact factor: 4.418

7.  Demystifying brain penetration in central nervous system drug discovery. Miniperspective.

Authors:  Li Di; Haojing Rong; Bo Feng
Journal:  J Med Chem       Date:  2012-11-06       Impact factor: 7.446

8.  Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985).

Authors:  R A Prentis; Y Lis; S R Walker
Journal:  Br J Clin Pharmacol       Date:  1988-03       Impact factor: 4.335
  8 in total

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