Literature DB >> 11311053

Property-based design: optimization of drug absorption and pharmacokinetics.

H van De Waterbeemd1, D A Smith, K Beaumont, D K Walker.   

Abstract

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Year:  2001        PMID： 11311053     DOI： 10.1021/jm000407e

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  55 in total

1.  Application of parallel liquid chromatography/mass spectrometry for high throughput microsomal stability screening of compound libraries.

Authors:  Rongda Xu; Csaba Nemes; Kelly M Jenkins; Robyn A Rourick; Daniel B Kassel; Charles Z C Liu
Journal:  J Am Soc Mass Spectrom       Date:  2002-02       Impact factor: 3.109

2.  Virtual screening and evaluation of Ketol-Acid Reducto-Isomerase (KARI) as a putative drug target for Aspergillosis.

Authors:  Vivek K Morya; Shalini Kumari; Eun-Ki Kim
Journal:  Clin Proteomics       Date:  2012-02-03       Impact factor: 3.988

3.  Highly predictive and interpretable models for PAMPA permeability.

Authors:  Hongmao Sun; Kimloan Nguyen; Edward Kerns; Zhengyin Yan; Kyeong Ri Yu; Pranav Shah; Ajit Jadhav; Xin Xu
Journal:  Bioorg Med Chem       Date:  2016-12-31       Impact factor: 3.641

4.  Efficacy and cytotoxicity in cell culture of novel α-hydroxytropolone inhibitors of hepatitis B virus ribonuclease H.

Authors:  Elena Lomonosova; Jil Daw; Aswin K Garimallaprabhakaran; Nana B Agyemang; Yashkumar Ashani; Ryan P Murelli; John E Tavis
Journal:  Antiviral Res       Date:  2017-06-17       Impact factor: 5.970

5.  A 'rule of unity' for human intestinal absorption.

Authors:  S H Yalkowsky; J L H Johnson; T Sanghvi; S G Machatha
Journal:  Pharm Res       Date:  2006-08-24       Impact factor: 4.200

6.  Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.

Authors:  Wenhui Hu; Hantamalala Ralay Ranaivo; Saktimayee M Roy; Heather A Behanna; Laura K Wing; Lenka Munoz; Ling Guo; Linda J Van Eldik; D Martin Watterson
Journal:  Bioorg Med Chem Lett       Date:  2006-10-17       Impact factor: 2.823

Review 7.  Modeling kinetics of subcellular disposition of chemicals.

Authors:  Stefan Balaz
Journal:  Chem Rev       Date:  2009-05       Impact factor: 60.622

8.  Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection.

Authors:  Cyrus J Bacchi; Louis M Weiss; Schenella Lane; Benjamin Frydman; Aldonia Valasinas; Venodhar Reddy; Jerry S Sun; Laurence J Marton; Imitiaz A Khan; Magali Moretto; Nigel Yarlett; Murray Wittner
Journal:  Antimicrob Agents Chemother       Date:  2002-01       Impact factor: 5.191

9.  High-throughput evaluation of relative cell permeability between peptoids and peptides.

Authors:  Niclas C Tan; Peng Yu; Yong-Uk Kwon; Thomas Kodadek
Journal:  Bioorg Med Chem       Date:  2008-05-03       Impact factor: 3.641

10.  Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy.

Authors:  Haitao Ji; Sidhartha Tan; Jotaro Igarashi; Huiying Li; Matthew Derrick; Pavel Martásek; Linda J Roman; Jeannette Vásquez-Vivar; Thomas L Poulos; Richard B Silverman
Journal:  Ann Neurol       Date:  2009-02       Impact factor: 10.422
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