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Literature DB >> 24930829

2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site.

Kevin D Rynearson¹, Brian Charrette¹, Christopher Gabriel¹, Jesus Moreno¹, Mark A Boerneke¹, Sergey M Dibrov¹, Thomas Hermann².

Abstract

2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands were investigated.

Entities: Chemical Disease Gene Species

Keywords: Antivirals; HCV; RNA target; Translation inhibitor

Mesh：

Substances：

Year: 2014 PMID： 24930829 PMCID： PMC4114401 DOI： 10.1016/j.bmcl.2014.05.088

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

10 in total

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Journal: J Med Chem Date: 2005-11-17 Impact factor: 7.446

2. Functional architecture of HCV IRES domain II stabilized by divalent metal ions in the crystal and in solution.

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3. Molecular recognition between ligands and nucleic acids: novel pyridine- and benzoxazole-containing agents related to Hoechst 33258 that exhibit altered DNA sequence specificity deduced from footprinting analysis and spectroscopic studies.

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4. Aryl-substituted aminobenzimidazoles targeting the hepatitis C virus internal ribosome entry site.

Authors: Kejia Ding; Annie Wang; Mark A Boerneke; Sergey M Dibrov; Thomas Hermann
Journal: Bioorg Med Chem Lett Date: 2014-05-14 Impact factor: 2.823

5. Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches.

Authors: Sergey M Dibrov; Kejia Ding; Nicholas D Brunn; Matthew A Parker; B Mikael Bergdahl; David L Wyles; Thomas Hermann
Journal: Proc Natl Acad Sci U S A Date: 2012-03-19 Impact factor: 11.205

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8. Molecular docking and synthesis of novel quinazoline analogues as inhibitors of transcription factors NF-κB activation and their anti-cancer activities.

Authors: Lu Xu; Wade A Russu
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9. Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA.

Authors: Shou Zhou; Kevin D Rynearson; Kejia Ding; Nicholas D Brunn; Thomas Hermann
Journal: Bioorg Med Chem Date: 2013-04-02 Impact factor: 3.641

10. Identification of a series of benzoxazoles as potent 5-HT6 ligands.

Authors: Kevin G Liu; Jennifer R Lo; Thomas A Comery; Guo Ming Zhang; Jean Y Zhang; Dianne M Kowal; Deborah L Smith; Li Di; Edward H Kerns; Lee E Schechter; Albert J Robichaud
Journal: Bioorg Med Chem Lett Date: 2009-01-03 Impact factor: 2.823

10 in total

1. Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry.

Authors: Aline Umuhire Juru; Zhengguo Cai; Adina Jan; Amanda E Hargrove
Journal: Chem Commun (Camb) Date: 2020-03-24 Impact factor: 6.222

2. Nanopore-based conformational analysis of a viral RNA drug target.

Authors: Carolyn Shasha; Robert Y Henley; Daniel H Stoloff; Kevin D Rynearson; Thomas Hermann; Meni Wanunu
Journal: ACS Nano Date: 2014-05-29 Impact factor: 15.881

3. Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors.

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4. Ligand-responsive RNA mechanical switches.

Authors: Mark A Boerneke; Thomas Hermann
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Review 5. Studies of RNA Sequence and Structure Using Nanopores.

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Review 6. The Emerging Role of RNA as a Therapeutic Target for Small Molecules.

Authors: Colleen M Connelly; Michelle H Moon; John S Schneekloth
Journal: Cell Chem Biol Date: 2016-09-01 Impact factor: 8.116

Review 7. Small molecules targeting viral RNA.

Authors: Thomas Hermann
Journal: Wiley Interdiscip Rev RNA Date: 2016-06-16 Impact factor: 9.957