Literature DB >> 32104839

Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry.

Aline Umuhire Juru1, Zhengguo Cai1, Adina Jan1, Amanda E Hargrove1.   

Abstract

This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library.

Entities:  

Mesh：

Substances：

Year:  2020        PMID： 32104839      PMCID： PMC7218690          DOI： 10.1039/d0cc00266f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  41 in total

1.  Use of dynamic combinatorial chemistry for the identification of covalently appended residues that stabilize oligonucleotide complexes.

Authors:  Anthony Bugaut; Jean-Jacques Toulmé; Bernard Rayner
Journal:  Angew Chem Int Ed Engl       Date:  2004-06-14       Impact factor: 15.336

2.  Dynamic combinatorial chemistry.

Authors:  Peter T Corbett; Julien Leclaire; Laurent Vial; Kevin R West; Jean-Luc Wietor; Jeremy K M Sanders; Sijbren Otto
Journal:  Chem Rev       Date:  2006-09       Impact factor: 60.622

Review 3.  Dynamic imine chemistry.

Authors:  Matthew E Belowich; J Fraser Stoddart
Journal:  Chem Soc Rev       Date:  2012-02-06       Impact factor: 54.564

4.  Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1.

Authors:  JuYeon Lee; Yugang Bai; Ullas V Chembazhi; Shaohong Peng; Kevin Yum; Long M Luu; Lauren D Hagler; Julio F Serrano; H Y Edwin Chan; Auinash Kalsotra; Steven C Zimmerman
Journal:  Proc Natl Acad Sci U S A       Date:  2019-04-11       Impact factor: 11.205

Review 5.  Hierarchy of RNA functional dynamics.

Authors:  Anthony M Mustoe; Charles L Brooks; Hashim M Al-Hashimi
Journal:  Annu Rev Biochem       Date:  2014-03-05       Impact factor: 23.643

6.  Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs.

Authors:  Matthew D Disney; Audrey M Winkelsas; Sai Pradeep Velagapudi; Mark Southern; Mohammad Fallahi; Jessica L Childs-Disney
Journal:  ACS Chem Biol       Date:  2016-04-20       Impact factor: 5.100

7.  Influence of dimethylsulfoxide on RNA structure and ligand binding.

Authors:  Janghyun Lee; Catherine E Vogt; Mitchell McBrairty; Hashim M Al-Hashimi
Journal:  Anal Chem       Date:  2013-09-25       Impact factor: 6.986

8.  Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays.

Authors:  Joanna Sztuba-Solinska; Shilpa R Shenoy; Peter Gareiss; Lauren R H Krumpe; Stuart F J Le Grice; Barry R O'Keefe; John S Schneekloth
Journal:  J Am Chem Soc       Date:  2014-05-28       Impact factor: 16.383

9.  High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble.

Authors:  Laura R Ganser; Janghyun Lee; Atul Rangadurai; Dawn K Merriman; Megan L Kelly; Aman D Kansal; Bharathwaj Sathyamoorthy; Hashim M Al-Hashimi
Journal:  Nat Struct Mol Biol       Date:  2018-05-04       Impact factor: 15.369

10.  Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution.

Authors:  Kaiming Zhang; Shanshan Li; Kalli Kappel; Grigore Pintilie; Zhaoming Su; Tung-Chung Mou; Michael F Schmid; Rhiju Das; Wah Chiu
Journal:  Nat Commun       Date:  2019-12-03       Impact factor: 14.919
View more
  4 in total

1.  Small molecule-RNA targeting: starting with the fundamentals.

Authors:  Amanda E Hargrove
Journal:  Chem Commun (Camb)       Date:  2020-11-26       Impact factor: 6.222

2.  Gene drive that results in addiction to a temperature-sensitive version of an essential gene triggers population collapse in Drosophila.

Authors:  Georg Oberhofer; Tobin Ivy; Bruce A Hay
Journal:  Proc Natl Acad Sci U S A       Date:  2021-12-07       Impact factor: 12.779

3.  Expanded DNA and RNA Trinucleotide Repeats in Myotonic Dystrophy Type 1 Select Their Own Multitarget, Sequence-Selective Inhibitors.

Authors:  Lauren D Hagler; Long M Luu; Marco Tonelli; JuYeon Lee; Samuel M Hayes; Sarah E Bonson; J Ignacio Vergara; Samuel E Butcher; Steven C Zimmerman
Journal:  Biochemistry       Date:  2020-09-10       Impact factor: 3.162

4.  Quantitative Structure-Activity Relationship (QSAR) Study Predicts Small-Molecule Binding to RNA Structure.

Authors:  Zhengguo Cai; Martina Zafferani; Olanrewaju M Akande; Amanda E Hargrove
Journal:  J Med Chem       Date:  2022-05-06       Impact factor: 8.039
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.