Hung-Tao Yi1, Yu-Cheng Hsieh2, Tsu-Juey Wu1, Jin-Long Huang1, Wei-Wen Lin3, Kae-Woei Liang1, Chieh-Shou Su1, Wan-Jane Tsai4, Kuo-Yang Wang5. 1. Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Clinical Medicine and Cardiovascular Research Institute, Department of Medicine, National Yang-Ming University, Taipei, Taiwan. 2. Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Clinical Medicine and Cardiovascular Research Institute, Department of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Financial and Computational Mathematics, Providence University, Taichung, Taiwan. 3. Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Life Science, Tunghai University, Taichung, Taiwan. 4. Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan. 5. Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan; Division of Cardiology, Cardiovascular Research Group, Institute of Medicine, Chung-Shan Medical University Hospital, Taichung, Taiwan. Electronic address: wky830@gmail.com.
Abstract
OBJECTIVE: This aim of this study was to correlate heart rate variability (HRV) parameters to pulmonary arterial pressure (PAP) in patients with purely idiopathic pulmonary arterial hypertension (IPAH). BACKGROUND: HRV is decreased in patients with PAH. Whether HRV indices can be used to assess PAP in IPAH patients remains unclear. METHODS: HRV parameters obtained by 24-h ECG were evaluated in 26 IPAH patients and 51 controls. RESULTS: Time-domain HRV parameters (SDNN, p < 0.0001; SDANN, p < 0.0001; RMSSD, p = 0.006) were lower in IPAH patients. Frequency-domain indices (high-frequency power, HFP, p = 0.001; low-frequency power, LFP, p = 0.003; total power, TP, p = 0.001) were also decreased in IPAH patients. In IPAH patients, RMSSD (p = 0.001), HFP (p = 0.015), and LFP (p = 0.027) were significantly correlated with PAP. IPAH patients had longer QTc intervals (p < 0.0001) and more premature ventricular contractions (p < 0.0001) than controls. CONCLUSIONS: IPAH is associated with autonomic dysfunction. RMSSD, HFP, and LFP may be used as a supplemental tool to assess PAP in IPAH patients. IPAH patients with autonomic dysfunction are at high risk for ventricular arrhythmia.
OBJECTIVE: This aim of this study was to correlate heart rate variability (HRV) parameters to pulmonary arterial pressure (PAP) in patients with purely idiopathic pulmonary arterial hypertension (IPAH). BACKGROUND: HRV is decreased in patients with PAH. Whether HRV indices can be used to assess PAP in IPAH patients remains unclear. METHODS: HRV parameters obtained by 24-h ECG were evaluated in 26 IPAH patients and 51 controls. RESULTS: Time-domain HRV parameters (SDNN, p < 0.0001; SDANN, p < 0.0001; RMSSD, p = 0.006) were lower in IPAH patients. Frequency-domain indices (high-frequency power, HFP, p = 0.001; low-frequency power, LFP, p = 0.003; total power, TP, p = 0.001) were also decreased in IPAH patients. In IPAH patients, RMSSD (p = 0.001), HFP (p = 0.015), and LFP (p = 0.027) were significantly correlated with PAP. IPAH patients had longer QTc intervals (p < 0.0001) and more premature ventricular contractions (p < 0.0001) than controls. CONCLUSIONS: IPAH is associated with autonomic dysfunction. RMSSD, HFP, and LFP may be used as a supplemental tool to assess PAP in IPAH patients. IPAH patients with autonomic dysfunction are at high risk for ventricular arrhythmia.
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