Huong Nguyen1, Adeline Ruyssen-Witrand2, Frédérique Gandjbakhch1, Arnaud Constantin3, Violaine Foltz1, Alain Cantagrel3. 1. Rheumatology Department, Purpan Hospital, UMR 1027 Inserm, UMR 1027, Université Paul Sabatier Toulouse 3, Toulouse, Rheumatology Department, Pitie Salpetriere Hospital, Paris and UMR 1043, Inserm, CPTP Toulouse Purpan, Toulouse, France. 2. Rheumatology Department, Purpan Hospital, UMR 1027 Inserm, UMR 1027, Université Paul Sabatier Toulouse 3, Toulouse, Rheumatology Department, Pitie Salpetriere Hospital, Paris and UMR 1043, Inserm, CPTP Toulouse Purpan, Toulouse, France. Rheumatology Department, Purpan Hospital, UMR 1027 Inserm, UMR 1027, Université Paul Sabatier Toulouse 3, Toulouse, Rheumatology Department, Pitie Salpetriere Hospital, Paris and UMR 1043, Inserm, CPTP Toulouse Purpan, Toulouse, France. Rheumatology Department, Purpan Hospital, UMR 1027 Inserm, UMR 1027, Université Paul Sabatier Toulouse 3, Toulouse, Rheumatology Department, Pitie Salpetriere Hospital, Paris and UMR 1043, Inserm, CPTP Toulouse Purpan, Toulouse, France. adruyssen@hotmail.com. 3. Rheumatology Department, Purpan Hospital, UMR 1027 Inserm, UMR 1027, Université Paul Sabatier Toulouse 3, Toulouse, Rheumatology Department, Pitie Salpetriere Hospital, Paris and UMR 1043, Inserm, CPTP Toulouse Purpan, Toulouse, France. Rheumatology Department, Purpan Hospital, UMR 1027 Inserm, UMR 1027, Université Paul Sabatier Toulouse 3, Toulouse, Rheumatology Department, Pitie Salpetriere Hospital, Paris and UMR 1043, Inserm, CPTP Toulouse Purpan, Toulouse, France. Rheumatology Department, Purpan Hospital, UMR 1027 Inserm, UMR 1027, Université Paul Sabatier Toulouse 3, Toulouse, Rheumatology Department, Pitie Salpetriere Hospital, Paris and UMR 1043, Inserm, CPTP Toulouse Purpan, Toulouse, France.
Abstract
OBJECTIVES: The aims of this study were to assess the prevalence of US-detected residual synovitis in patients with RA in clinical remission (CR) and evaluate its predictive value for relapse and structural progression. METHODS: We performed a systematic literature search of Medline, Embase and rheumatology meeting databases from 1 January 2001 to 28 May 2012. The prevalence of US grey-scale (USGS) signals (synovial hypertrophy or joint effusion) and power Doppler (PD) signals were collected, taking into account CR definitions [44-joint DAS (DAS44), 28-joint DAS (DAS28), SDAI, ACR 1981 or ACR/European League Against Rheumatism 2011], stage of RA (early or long-standing) and US examination (from 5 to 44 joints assessed). A meta-analysis assessing the risk of relapse or structural progression in patients with synovitis involved the Mantel-Haenszel method. RESULTS: We included 19 studies of 1618 patients, 1369 in remission. The prevalence of USGS positive (USGS+), USGS+/PD negative (PD-), USGS+/PD positive (PD+) and USGS negative (USGS-/PD- was 84%, 41%, 44% and 15%, respectively. The prevalence of USGS+ or USGS+/PD+ was comparable among CR definitions and US methods. The prevalence of USGS+ and USGS+/PD+ was greater for long-standing than early RA (P < 0.001). Meta-analyses of five studies (271 patients), three studies (173 patients) and two studies (798 joints) revealed an association of USGS+/PD+ and risk of relapse [odds ratio (OR) 3.2 (95% CI 1.8, 5.9), P = 0.0001, I(2) = 0%] and structural progression in individual patients [OR 9.13 (95% CI 1.1, 74.3), P = 0.04, I(2) = 43%] and joints [OR 6.95 (95% CI 3.4, 13.9), P < 0.0001, I(2) = 6%] over 1-2 years. CONCLUSION: US-detected residual synovitis is frequent and predicts the risk of relapse and structural progression in RA patients with CR.
OBJECTIVES: The aims of this study were to assess the prevalence of US-detected residual synovitis in patients with RA in clinical remission (CR) and evaluate its predictive value for relapse and structural progression. METHODS: We performed a systematic literature search of Medline, Embase and rheumatology meeting databases from 1 January 2001 to 28 May 2012. The prevalence of US grey-scale (USGS) signals (synovial hypertrophy or joint effusion) and power Doppler (PD) signals were collected, taking into account CR definitions [44-joint DAS (DAS44), 28-joint DAS (DAS28), SDAI, ACR 1981 or ACR/European League Against Rheumatism 2011], stage of RA (early or long-standing) and US examination (from 5 to 44 joints assessed). A meta-analysis assessing the risk of relapse or structural progression in patients with synovitis involved the Mantel-Haenszel method. RESULTS: We included 19 studies of 1618 patients, 1369 in remission. The prevalence of USGS positive (USGS+), USGS+/PD negative (PD-), USGS+/PD positive (PD+) and USGS negative (USGS-/PD- was 84%, 41%, 44% and 15%, respectively. The prevalence of USGS+ or USGS+/PD+ was comparable among CR definitions and US methods. The prevalence of USGS+ and USGS+/PD+ was greater for long-standing than early RA (P < 0.001). Meta-analyses of five studies (271 patients), three studies (173 patients) and two studies (798 joints) revealed an association of USGS+/PD+ and risk of relapse [odds ratio (OR) 3.2 (95% CI 1.8, 5.9), P = 0.0001, I(2) = 0%] and structural progression in individual patients [OR 9.13 (95% CI 1.1, 74.3), P = 0.04, I(2) = 43%] and joints [OR 6.95 (95% CI 3.4, 13.9), P < 0.0001, I(2) = 6%] over 1-2 years. CONCLUSION: US-detected residual synovitis is frequent and predicts the risk of relapse and structural progression in RApatients with CR.
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