| Literature DB >> 24929144 |
Takeji Umemura1, Masao Ota2, Yoshihiko Katsuyama3, Shuichi Wada4, Hiromitsu Mori4, Atsushi Maruyama5, Soichiro Shibata6, Yuichi Nozawa6, Takefumi Kimura6, Susumu Morita6, Satoru Joshita6, Michiharu Komatsu6, Akihiro Matsumoto6, Atsushi Kamijo7, Masakazu Kobayashi8, Masato Takamatsu9, Kaname Yoshizawa10, Kendo Kiyosawa4, Eiji Tanaka6.
Abstract
Natural killer cells play a key role in the immune control of viral infections. Killer immunoglobulin-like receptors (KIRs) regulate natural killer cell activation and inhibition through the recognition of their cognate HLA class I ligands. We assessed the predictive factors of a sustained virological response (SVR) in 200 Japanese patients with chronic genotype 1b hepatitis C who were treated with telaprevir (TVR), pegylated-interferon-α2b (PEG-IFN), and ribavirin (RBV) triple therapy (92 patients) or PEG-IFN/RBV therapy alone (108 patients). Sixteen KIR genotypes, HLA-A, -B and -C ligands, and an interleukin (IL) 28B polymorphism (rs8099917) were analyzed. We observed that triple therapy, white blood cell count, hemoglobin value, hepatitis C viral load, a rapid virological response (RVR), IL28B TT genotype, and KIR3DL1-HLA-Bw4 genotype were associated with an SVR. In multivariate regression analysis, we identified an RVR (P < 0.000001; odds ratio [OR] = 20.95), the IL28B TT genotype (P = 0.00014; OR = 5.53), and KIR3DL1-HLA-Bw4 (P = 0.004, OR = 3.42) as significant independent predictive factors of an SVR. In conclusion, IL28B and KIR3DL1/HLA-Bw4 are independent predictors of an SVR in Japanese patients infected with genotype 1b HCV receiving TVR/PEG-IFN/RBV or PEG-IFN/RBV therapy.Entities:
Keywords: HCV; HLA; KIR; PEG-IFN; Telaprevir
Mesh：
Substances：
Year: 2014 PMID： 24929144 DOI： 10.1016/j.humimm.2014.06.003
Source DB: PubMed Journal: Hum Immunol ISSN： 0198-8859 Impact factor: 2.850