| Literature DB >> 24926011 |
Yuchen Xia1, Julie Lucifora1, Florian Reisinger1, Mathias Heikenwalder1, Ulrike Protzer2.
Abstract
Chisari et al. challenge our central conclusion that the hepatitis B virus (HBV) persistent form, the covalently closed circular DNA (cccDNA), is degraded in a noncytotoxic and specific fashion in the nucleus of infected hepatocytes. Specificity of the assays used, exclusion of cell division or death, and activity of APOBEC3 deaminases in the nucleus, however, were addressed in the paper.Entities:
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Year: 2014 PMID: 24926011 DOI: 10.1126/science.1254083
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728