Literature DB >> 2492442

Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: behavioral and biochemical evidence.

J L Cadet1, M Katz, V Jackson-Lewis, S Fahn.   

Abstract

Unilateral 6-hydroxydopamine (6-OHDA) injections into the striatum lead to the development of apomorphine-induced rotation in rats. The circling behavior was associated with significant decreases in dopamine, dihydroxyphenylacetic acid and homovanillic acid in the ipsilateral striatum. Pretreatments with either D-alpha-tocopherol or all-racemic-alpha-tocopherol caused significant attenuation of both the behavioral and biochemical abnormalities. These results are discussed in terms of their support for the free radical hypothesis of Parkinson's disease and for the role of antioxidants in the treatment of this neurodegenerative disorder.

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Year:  1989        PMID： 2492442     DOI： 10.1016/0006-8993(89)91530-8

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  20 in total

1.  EPC-K1, a hydroxyl radical scavenger, prevents 6-hydroxydopamine-induced dopamine depletion in the mouse striatum by up-regulation of catalase activity.

Authors:  H Kabuto; I Yokoi; E Iwata-Ichikawa; N Ogawa
Journal:  Neurochem Res       Date:  1999-12       Impact factor: 3.996

2.  Review of apoptosis vs. necrosis of substantia nigra pars compacta in Parkinson's disease.

Authors:  R M Kostrzewa
Journal:  Neurotox Res       Date:  2000       Impact factor: 3.911

Review 3.  Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man.

Authors:  M Gerlach; P Riederer
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

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Journal:  Acta Pharmacol Sin       Date:  2016-11-21       Impact factor: 6.150

5.  The copper chelator, D-penicillamine, does not attenuate MPTP induced dopamine depletion in mice.

Authors:  M B H Youdim; E Grünblatt; S Mandel
Journal:  J Neural Transm (Vienna)       Date:  2006-06-01       Impact factor: 3.575

Review 6.  Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice.

Authors:  J Lan; D H Jiang
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

7.  Zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] prevents 6-hydroxydopamine-induced dopamine depression in mouse striatum and increases superoxide scavenging activity in serum.

Authors:  Hideaki Kabuto; Masahiro Nishizawa; Mika Tada; Chie Higashio; Tsuyoshi Shishibori; Masahiro Kohno
Journal:  Neurochem Res       Date:  2005-03       Impact factor: 3.996

Review 8.  How do we fit ferroptosis in the family of regulated cell death?

Authors:  Howard O Fearnhead; Peter Vandenabeele; Tom Vanden Berghe
Journal:  Cell Death Differ       Date:  2017-10-06       Impact factor: 15.828

9.  Effects of zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] and eugenol [2-methoxy-4-(2-propenyl)phenol] on the pathological progress in the 6-hydroxydopamine-induced Parkinson's disease mouse model.

Authors:  Hideaki Kabuto; Tomoko T Yamanushi
Journal:  Neurochem Res       Date:  2011-07-19       Impact factor: 3.996

Review 10.  Neuroprotective strategies in Parkinson's disease : an update on progress.

Authors:  Silvia Mandel; Edna Grünblatt; Peter Riederer; Manfred Gerlach; Yona Levites; Moussa B H Youdim
Journal:  CNS Drugs       Date:  2003       Impact factor: 5.749
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